Gentamicin Loaded Zn2(bdc)2(dabco) Frameworks as Efficient Materials for Drug Delivery and Antibacterial Activity
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New drug delivery systems are very helpful in diagnosis and treatment of diseases through controlled and targeted drug delivery. They can increase bioavailability of drugs and reduce their side effects. Metal–organic frameworks (MOFs) are alternative drug delivery systems, which are suitable for targeted drug delivery due to their adjustable pore sizes and compatibility by adding some functional groups. Application of these compounds permits simultaneous use of several advantages including biocompatibility, the ability to absorb large amounts of drugs and control drug release. The present study was designed to provide Zn2(bdc)2(dabco) MOF and evaluate its performance in absorbing and releasing gentamicin. Characterization methods, such as FTIR, XRD, SEM, BET, UV–Vis spectroscopy and TGA, were employed to characterize the gentamicin-loaded Zn2(bdc)2(dabco) structure. The amount of drug release from Zn2(bdc)2(dabco) was measured in buffer solutions with 7.4 and 5.0 pHs. Furthermore, antibacterial properties of the drug, MOF and drug-loaded MOF have been investigated against Gram-positive and Gram-negative bacteria. This study shows the potential of using Zn2(bdc)2(dabco) frameworks for controlled release of antibiotic drugs.
KeywordsFrameworks Drug delivery Antibacterial activity Antibiotic drugs
This work has been financially supported by Azarbaijan Shahid Madani University under the grant number 96/603.
- 4.A. Gabizon, Stealth liposomes and tumor targeting: one step further in the quest for the magic bullet. Clin. Cancer Res. 7, 223–225 (2001)Google Scholar
- 27.T. Slattery et al., Graft-rejection and toxicity following bone marrow transplantation in relation to busulfan pharmacokinetics. Bone Marrow Transplant. 16, 31–42 (1995)Google Scholar
- 33.N. Manjunatha, S. Vasanti, N. Rajesh, N. Uma, Formulation and evaluation of biopolymer based microspheres for nasal drug delivery. Int. J. PharmTech Res. 2(1), 856 (2010)Google Scholar