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Polysiloxanes With Quaternary Ammonium Salt Biocidal Functions and Their Behavior When Incorporated Into a Silicone Elastomer Network

  • Witold Fortuniak
  • Urszula Mizerska
  • Julian Chojnowski
  • Teresa Basinska
  • Stanislaw Slomkowski
  • Mohamed M. Chehimi
  • Agnieszka Konopacka
  • Katarzyna Turecka
  • Władysław Werel
Article

Abstract

Polysiloxanes of various structures having biocidal quaternary ammonium salt (QAS) groups pendant to the polymer chain were prepared. Their antibacterial activities were compared in aqueous solution. Selected polysiloxanes were linear polydimethylsiloxanes having 20% siloxane units substituted at silicon by 3(dimethyl-n-octylammonio)propyl chloride or 3(dimethyl-n-hexadecylammonio)propyl chloride and terminated by silanol functions at both chain ends. They were crosslinked and also incorporated by co-crosslinking into an RTV (room temperature vulcanized) silicone elastomer. Bacteriocidal activities of surfaces of the crosslinked biocidal polysiloxanes and of the elastomers having incorporated these polymers were determined by the colony count method. Thousand-fold reduction of Staphylococcus aureus in contact with the dimethyl-n-octylammonio substituted polymer was achieved in 2 min and in contact with the elastomer containing 20 wt% of this polymer in 15 min, although the density of the QAS was as low as 0.36 mmol/g. The surface structure and properties of the elastomers were studied by XPS, contact angle, AFM and model human serum protein (HSA) adsorption. Water sorption by this material was also studied. The concentration of QAS groups on the elastomer surface depended strongly on the material surroundings. No QAS was found on the surface in ultrahigh vacuum, while a strong enhancement of QAS presence on the surface was observed when it was in contact with water or water vapor. Hydrophobicity of the elastomer surface was little affected by the incorporated biocidal QAS-containing polysiloxane when the elastomer was kept in air. This material showed little ability to adsorb the HSA protein from its aqueous solution.

Keywords

Biocidal polymers Antimicrobial polymers Silicone elastomers Silicone rubber Polysiloxanes Functional polysiloxanes 

Notes

Acknowledgments

The research was supported from the state funds, Project N N205 012834. The supports from The Medical University of Gdansk and from The Center of Molecular and Macromolecular Studies of the Polish Academy of Sciences also are greatly appreciated. The authors are indebted to Professor Martel Zeldin from the University of Richmond, Virginia USA, for the improvement of the language of this paper and to Bartosz Głębocki M.Sc. from the Center of Molecular and Macromolecular Studies for AFM measurements.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Witold Fortuniak
    • 1
  • Urszula Mizerska
    • 1
  • Julian Chojnowski
    • 1
  • Teresa Basinska
    • 1
  • Stanislaw Slomkowski
    • 1
  • Mohamed M. Chehimi
    • 2
  • Agnieszka Konopacka
    • 3
  • Katarzyna Turecka
    • 3
  • Władysław Werel
    • 3
  1. 1.Centre of Molecular and Macromolecular StudiesPolish Academy of SciencesLodzPoland
  2. 2.Interfaces, Traitements, Organisation and Dynamique des Systèmes (ITODYS)Université Paris Diderot-CNRS (UMR 7086)ParisFrance
  3. 3.Department of Pharmacy, Chair of Pharmaceutical MicrobiologyGdansk Medical UniversityGdanskPoland

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