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Journal of Immigrant and Minority Health

, Volume 15, Issue 6, pp 1048–1056 | Cite as

Changing Blood Lead Levels and Oxidative Stress with Duration of Residence Among Taiwan Immigrants

  • Wei-Te Wu
  • Chin-Ching Wu
  • Yu-Jen Lin
  • Chen-Yang Shen
  • Tsung-Yun Liu
  • Chun-Yuh Yang
  • Saou-Hsing Liou
  • Trong-Neng Wu
Original Paper

Abstract

Immigrants lack appropriate health care access and other resources needed to reduce their exposure to preventable environmental health risks. Little is known about the impact of lead exposure and oxidative stress among immigrants. Thus, this study was to examine the differences between the blood lead levels (BLLs) and oxidative stress levels of immigrants and non-immigrants, and to investigate the determinants of increased BLLs or oxidative stress levels among immigrants. We collected demographic data of 239 immigrant women and 189 non-immigrant women who resettled in the central area of Taiwan. Each study participant provided blood samples for genotyping and for measuring blood metal levels and oxidative stress. Recent immigrants were at risk for elevated BLLs. Decreased BLLs, malondialdehyde (MDA), and increased blood selenium levels were significantly associated with duration of residence in Taiwan. Elevated BLLs and MDA in recent immigrants may serve as a warning sign for the health care system. The nation’s health will benefit from improved regulation of living environments, thereby improving the health of immigrants.

Keywords

Blood lead levels (BLLs) Oxidative stress Immigrants Duration of residence 

Notes

Acknowledgments

This work was supported by the National Science Council, Taipei, Taiwan (NSC 97-2314-B-039-016-MY2). The authors thank all the study participants and WC Shih, MJ Hong, SJ Lin, and the staff from the Public Health Center in central Taiwan.

References

  1. 1.
    International Organization for Migration. Facts and figures. http://www.iom.int/jahia/Jahia/about-migration/facts-and-figures/lang/en. Accessed 2012.
  2. 2.
    Ministry of the Interior ROC. The statistics of marriage registration and number of birth by Bride’s Nationality in Taiwan. 2011.Google Scholar
  3. 3.
    Tong S, McMichael AJ, Baghurst PA. Interactions between environmental lead exposure and sociodemographic factors on cognitive development. Arch Environ Health. 2000;55:330–5.PubMedCrossRefGoogle Scholar
  4. 4.
    Fewtrell LJ, Pruss-Ustun A, Landrigan P, Ayuso-Mateos JL. Estimating the global burden of disease of mild mental retardation and cardiovascular diseases from environmental lead exposure. Environ Res. 2004;94:120–33.PubMedCrossRefGoogle Scholar
  5. 5.
    Bellinger DC. Teratogen update: lead and pregnancy. Birth Defects Res A Clin Mol Teratol. 2005;73:409–20.PubMedCrossRefGoogle Scholar
  6. 6.
    ATSDR. Toxicological profile for lead: agency for toxic substances and disease registry 2007.Google Scholar
  7. 7.
    Landrigan PJ. The worldwide problem of lead in petrol. Bull World Health Organ. 2002;80:768.PubMedGoogle Scholar
  8. 8.
    CDC. Elevated blood lead levels among internationally adopted children–United States, 1998. JAMA. 2000;283:1416–8.CrossRefGoogle Scholar
  9. 9.
    Lead exposure among females of childbearing age–United States, 2004. Morb Mortal Wkly Rep 2007;56:397–400.Google Scholar
  10. 10.
    Binns HJ, Kim D, Campbell C. Targeted screening for elevated blood lead levels: populations at high risk. Pediatrics. 2001;108:1364–6.PubMedCrossRefGoogle Scholar
  11. 11.
    Hayashi Y, Doi K, Yagishita M, Kuwata M. Urban transport sustainability: Asian trends, problems and policy practices. Europ J Transp Infrast Res. 2004;4:27–45.Google Scholar
  12. 12.
    Kosnett MJ, Wedeen RP, Rothenberg SJ, Hipkins KL, Materna BL, Schwartz BS, Hu H, Woolf A. Recommendations for medical management of adult lead exposure. Environ Health Perspect. 2007;115:463–71.PubMedCrossRefGoogle Scholar
  13. 13.
    Zhao Y, Wang L, Shen HB, Wang ZX, Wei QY, Chen F. Association between delta-aminolevulinic acid dehydratase (ALAD) polymorphism and blood lead levels: a meta-regression analysis. J Toxicol Environ Health A. 2007;70:1986–94.PubMedCrossRefGoogle Scholar
  14. 14.
    Kelada SN, Shelton E, Kaufmann RB, Khoury MJ. Delta-aminolevulinic acid dehydratase genotype and lead toxicity: a HuGE review. Am J Epidemiol. 2001;154:1–13.PubMedCrossRefGoogle Scholar
  15. 15.
    Feder JN, Penny DM, Irrinki A, Lee VK, Lebron JA, Watson N, Tsuchihashi Z, Sigal E, Bjorkman PJ, Schatzman RC. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci USA. 1998;95:1472–7.PubMedCrossRefGoogle Scholar
  16. 16.
    Wang FT, Hu H, Schwartz J, Weuve J, Spiro AS, Sparrow D, Nie H, Silverman EK, Weiss ST, Wright RO. Modifying effects of the HFE polymorphisms on the association between lead burden and cognitive decline. Environ Health Perspect. 2007;115:1210–5.PubMedCrossRefGoogle Scholar
  17. 17.
    Rezende VB, Barbosa F Jr, Montenegro MF, Sandrim VC, Gerlach RF, Tanus-Santos JE. Haplotypes of vitamin D receptor modulate the circulating levels of lead in exposed subjects. Arch Toxicol. 2008;82:29–36.PubMedCrossRefGoogle Scholar
  18. 18.
    Zmuda JM, Cauley JA, Ferrell RE. Molecular epidemiology of vitamin D receptor gene variants. Epidemiol Rev. 2000;22:203–17.PubMedCrossRefGoogle Scholar
  19. 19.
    Tsuchihashi Z, Hansen SL, Quintana L, Kronmal GS, Mapa FA, Feder JN, Wolff RK. Transferrin receptor mutation analysis in hereditary hemochromatosis patients. Blood Cells Mol Dis. 1998;24:317–21.PubMedCrossRefGoogle Scholar
  20. 20.
    Ahamed M, Siddiqui MK. Low level lead exposure and oxidative stress: current opinions. Clin Chim Acta. 2007;383:57–64.PubMedCrossRefGoogle Scholar
  21. 21.
    Armstrong D, Browne R. The analysis of free radicals, lipid peroxides, antioxidant enzymes and compounds related to oxidative stress as applied to the clinical chemistry laboratory. Adv Exp Med Biol. 1994;366:43–58.PubMedCrossRefGoogle Scholar
  22. 22.
    Yagi K. Simple assay for the level of total lipid peroxides in serum or plasma. Methods Mol Biol. 1998;108:101–6.PubMedGoogle Scholar
  23. 23.
    Marklund S. Distribution of CuZn superoxide dismutase and Mn superoxide dismutase in human tissues and extracellular fluids. Acta Physiol Scand Suppl. 1980;492:19–23.PubMedGoogle Scholar
  24. 24.
    CDC. Laboratory procedure manual-lead, cadmium, and mercury in whole blood, Atlanta, GA 30333: Centers for Disease Control and Prevention 2004.Google Scholar
  25. 25.
    Urquia ML, Frank JW, Moineddin R, Glazier RH. Immigrants’ duration of residence and adverse birth outcomes: a population-based study. BJOG. 2010;117:591–601.PubMedCrossRefGoogle Scholar
  26. 26.
    Goel MS, McCarthy EP, Phillips RS, Wee CC. Obesity among US immigrant subgroups by duration of residence. JAMA. 2004;292:2860–7.PubMedCrossRefGoogle Scholar
  27. 27.
    Hernandez-Avila M, Gonzalez-Cossio T, Palazuelos E, Romieu I, Aro A, Fishbein E, Peterson KE, Hu H. Dietary and environmental determinants of blood and bone lead levels in lactating postpartum women living in Mexico City. Environ Health Perspect. 1996;104:1076–82.PubMedCrossRefGoogle Scholar
  28. 28.
    Moller P, Loft S. Oxidative damage to DNA and lipids as biomarkers of exposure to air pollution. Environ Health Perspect. 2010;118:1126–36.PubMedCrossRefGoogle Scholar
  29. 29.
    Yesilbursa D, Serdar Z, Serdar A, Sarac M, Coskun S, Jale C. Lipid peroxides in obese patients and effects of weight loss with orlistat on lipid peroxides levels. Int J Obes (Lond). 2005;29:142–5.CrossRefGoogle Scholar
  30. 30.
    Fernandez-Sanchez A, Madrigal-Santillan E, Bautista M, Esquivel-Soto J, Morales-González A, Esquivel-Chirino C, Durante-Montiel I, Sánchez-Rivera G, Valadez-Vega C, Morales-González JA. Inflammation, oxidative stress, and obesity. Int J Mol Sci. 2011;12:3117–32.PubMedCrossRefGoogle Scholar
  31. 31.
    Combs GF Jr. Selenium in global food systems. Br J Nutr. 2001;85:517–47.PubMedCrossRefGoogle Scholar
  32. 32.
    Rayman MP. The importance of selenium to human health. Lancet. 2000;356:233–41.PubMedCrossRefGoogle Scholar
  33. 33.
    Karapanou O, Papadimitriou A. Determinants of menarche. Reprod Biol Endocrinol. 2010;8:115.PubMedCrossRefGoogle Scholar
  34. 34.
    Patrick L. Lead toxicity part II: the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity. Altern Med Rev. 2006;11:114–27.PubMedGoogle Scholar
  35. 35.
    Romieu I, Castro-Giner F, Kunzli N, Sunyer J. Air pollution, oxidative stress and dietary supplementation: a review. Eur Respir J. 2008;31:179–97.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Wei-Te Wu
    • 1
  • Chin-Ching Wu
    • 2
  • Yu-Jen Lin
    • 1
  • Chen-Yang Shen
    • 3
  • Tsung-Yun Liu
    • 4
  • Chun-Yuh Yang
    • 5
  • Saou-Hsing Liou
    • 1
    • 2
  • Trong-Neng Wu
    • 1
    • 6
  1. 1.Division of Environmental Health and Occupational MedicineNational Health Research InstitutesMiaoli CountyTaiwan
  2. 2.Department of Public HealthChina Medical UniversityTaichungTaiwan
  3. 3.Institute of Biomedical SciencesAcademia SinicaTaipeiTaiwan
  4. 4.Institute of Environmental and Occupational Health SciencesNational Yang Ming UniversityTaipeiTaiwan
  5. 5.Institute of Public HealthKaohsiung Medical UniversityKaohsiungTaiwan
  6. 6.Graduate Institute of Biostatistics, College of Public HealthChina Medical UniversityTaichungTaiwan

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