The objective of this study is to identify the predictors of the QOL’s domains, specifically, to understand the relationship between biological markers, psychological variables and QOL of HIV/AIDS patients. Cross-sectional developed with 94 individuals with HIV/AIDS, who attend the outpatient clinic specialty and have had an antiretroviral prescription for 3 months. WHOQOL-Bref (QOL), CEAT-VIH (treatment adherence), Meaning in life scale (ML) and PANAS (affects), and sociodemographic and clinical questionnaire. The results of the predictive models of the QOL’s domains, when controlling for the viral load and the CD4 + T cell count, encompass affect balance, treatment adherence and meaning in life with the highest explained variance in the predictive models of QOL in physical 37.4% and psychological 33.9% domains. The affect balance is a predictor of all QOL’s domains and treatment adherence is a predictor of three of them. ML is a predictor of the psychological and environmental domains. This study emphasizes the importance of affect balance, treatment adherence and meaning in life for the QOL in HIV.
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Audet, C., Wagner, L., & Wallston, K. (2015). Finding meaning in life while living with HIV: validation of a novel HIV meaningfulness scale among HIV-infected participants living in Tennessee. BMC Psychology. https://doi.org/10.1186/s40359-015-0070-7.
Balthip, Q. (2010). Achieving harmony of mind: A grounded theory study of people living with HIV/AIDS in the Thai context. Unpublished doctoral dissertation, Massey University, Palmerston North, New Zealand.
Balthip, Q., & Purnell, M. (2014). Pursuing meaning and purpose in life among Thai adolescents living with HIV: A grounded theory study. Journal of the Association of Nurses in AIDS CARE. https://doi.org/10.1016/j.jana.2014.03.004.
Beard, J., Feeley, F., & Rosen, S. (2009). Economic and quality of life outcomes of antiretroviral therapy for HIV/AIDS in developing countries: a systematic literature review. AIDS Care, 21(11), 1343–1356. https://doi.org/10.1080/09540120902889926.
Cardona-Arias, J. A., & Higuita-Gutierrez, L. F. (2014). Impact of HIV/AIDS on quality of life: Meta-analysis 2002–2012. Revista espanola de salud publica, 88(1), 87–101. https://doi.org/10.4321/S1135-57272014000100006.
Centre for Disease Control. (1993). Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. Retirado de https://www.ncbi.nlm.nih.gov/pubmed/8093740.
Chida, Y., & Vedhara, K. (2009). Adverse psychosocial factors predict poorer prognosis in HIV disease: A meta-analytic review of prospective investigations. Brain, Behavior, and Immunity, 23(4), 434–445. https://doi.org/10.1016/j.bbi.2009.01.013.
Ciesla, J. A., & Roberts, J. E. (2001). Meta-analysis of the relationship between HIV infection and risk for depressive disorders. American Journal of Psychiatry, 158, 725–730.
Cooper, V., Clatworthy, J., Harding, R., Whetham, J., & Emerge Consortium. (2017). Measuring quality of life among people living with HIV: A sistematic review of reviews. Health and Quality of Life Outcomes. https://doi.org/10.1186/s12955-017-0778-6.
Degroote, S., Vogelaers, D., & Vandijck, D. M. (2014). What determines health-related quality of life among people living with HIV: An updated review of the literature. Archives of Public Health, 72, 40. https://doi.org/10.1186/2049-3258-72-40.
Denvir, M. A., Lee, A. J., Rysdale, J., Walker, A., Eteiba, H., Starkey, I. R., et al. (2006). Influence of socioeconomic status on clinical outcomes and quality of life after percutaneous coronary intervention. Journal of Epidemiology and Community Health, 60, 1085–1088. https://doi.org/10.1136/jech.2005.044255.
Fleck, M. A. (2006). O projecto WHOQOL: Desenvolvimentos e aplicações. Psiquiatria Clínica, 27(1), 5–13.
Galinha, I., & Ribeiro, J. P. (2005). Contribuição para o estudo da versão portuguesa da Positive and Negative Affect Schedule (PANAS): II—Estudo psicométrico. Análise Psicológica, 23(2), 219–227.
Gonzalez, J. S., Batchelder, A., Psaros, C., & Safren, S. A. (2011). Depression and HIV/AIDS treatment nonadherence: A review and meta-analysis. Journal of Acquir Immune Defic Syndr. https://doi.org/10.1097/qai.0b013822d490a.
Guerra, M., Lencastre, L., Silva, E., & Teixeira, P. (2017). Meaning in life in medical settings: A new measure correlating with psychological variables in disease. Cogent Psychology, 4, 1286747. https://doi.org/10.1080/23311908.2017.1286747.
Heintzelman, S., & King, L. (2014). Life is pretty meaningful. American Psychologist, 69(6), 561–574.
Jim, H., Purnell, J. Q., Richardson, S. A., Golden-Kreutz, D., & Andersen, B. L. (2006). Measuring meaning in life following cancer. Quality of Life Research, 15(8), 1355–1371. https://doi.org/10.1007/s11136-00-6-0028-6.
Koydemir, S., Şimşek, Ö., Schütz, A., & Tipandjan, A. (2013). Differences in how trait emotional intelligence predicts life satisfaction: The role of affect balance versus social support in India and Germany. Journal of Happiness Studies, 14(1), 51–66.
Li, J., Mo, P., Wu, A., & Lau, J. (2017). Roles of self-stigma, social support, and positive and negative affects as determinants of depressive symptoms among HIV infected men who have sex with men in China. AIDS and Behavior, 21, 261–273. https://doi.org/10.1007/s10461-016-1321-1.
Liping, M., Peng, X., Haijiang, L., Lahong, J., & Fan, L. (2015). Quality of life of people living with HIV/AIDS: A cross-sectional study in Zhejiang Province. China: Plos One. https://doi.org/10.1371/journal.pone.0135705.
Pallant, J. (2011). SPSS survival manual. Philadelphia: Open University Press.
Parienti, J. J., Bangsberg, D. R., Verdon, R., & Gardner, E. M. (2009). Better adherence with once-daily antiretroviral regimens: A meta-analysis. Clinical Infectious Diseases, 48(4), 484–488.
Park, N., Park, M., & Peterson, C. (2010). When is the search for meaning related to life satisfaction? Applied Psychology: Health and Well-being, 2, 1–13.
Pinto, C., & Guerra, M. P. (2018). The influence of meaning in life and depression in multiple sclerosis. Análise Psicológica, 4(36), 439–453. https://doi.org/10.14417/ap1394.
Reis, A., Guerra, M., & Lencastre, L. (2013a). Treatment adherence, quality of life and clinical variables in HIV/AIDS Infection. World Journal of AIDS, 3(3), 239–250. https://doi.org/10.4236/wja.2013.33032.
Reis, A., Guerra, M., & Lencastre, L. (2013b). Treatment adherence and subjective well-being in HIV/AIDS infection. AIDS Care. https://doi.org/10.1080/09540121.2013.793276.
Reis, A., Lencastre, L., Guerra, M., & Remor, E. (2009). Adaptação portuguesa do “Cuestionario para la Evaluación de la adhesión al Tratamiento Antirretroviral—VIH”. Psicologia: Saúde & Doenças, 10(2), 175–191.
Reis, A., Lencastre, L., Guerra, M., & Remor, E. (2010). Relação entre a sintomatologia Psicopatológica, adesão ao tratamento e qualidade de vida na infecção pelo HIV e Aids. Psicologia: Reflexão e Crítica, 23(3), 187–196. https://doi.org/10.1590/s0102-79722010000300002.
Remor, E. (2002). Valoración de la adhesión al tratamiento antirretroviral en pacientes VIH+. Psicothema, 14(2), 262–267.
Rzeszutek, M., & Gruszczynska, E. (2018). Consistency of health-related quality of life among people living with HIV: Latent state-trait analysis. Health and Quality of Life Outcomes. https://doi.org/10.1186/s12955-018-0929-4.
Schroecksnadel, K., Sarcletti, M., Winkler, C., Mumelter, B., Weiss, G., Funchs, D., et al. (2008). Quality of life and immune activation in patients with HIV-infection. Brain, Behavior, and Immunity, 22, 881–889.
Skevington, S. M., Lofty, M., O’Connell, K. A., & WHOQOL Group. (2004). The World Health Organization’s WHOQOL-Bref quality of life assessment: Psychometric properties and results of the international field trial. A report from the WHOQOL Group. Quality of Life Research, 13(2), 299–310.
Spindler, H., Denollet, J., Kruse, J., & Pedersen, S. S. (2009). Positive affect and negative affect correlate differently with distress and health-related quality of life in patients with cardiac conditions: Validation of the Danish Global Mood Scale. Journal of Psychosomatic Research, 67, 57–65.
Stauber, S., Schmid, J., Saner, H., Znoj, H., Saner, G., Grolimund, J., et al. (2013). Health-related quality of life is associated with positive affect in patients with coronary heart disease entering cardiac rehabilitation. Journal of Clinical Psychology in Medical Settings, 20, 79–87. https://doi.org/10.1007/s10880-012-9311-6.
UNAIDS. (2019). Global AIDS monitoring 2019: Indicators for monitoring the 2016 political declaration on ending AIDS. Retrieved from http://aidsinfo.unaids.org/.
Vaz Serra, A., Canavarro, M. C., Simões, M., Pereira, M., Gameiro, S., Quartilho, M. J., et al. (2006). Estudos psicométricos do instrumento de avaliação da qualidade de vida da Organização Mundial de Saúde (WHOQOL-Bref) para português de Portugal. Psiquiatria Clínica, 27(1), 41–49.
WHOQOL Group. (1998). Development of the World Health Organization WHOQOL-BREF quality of life assessment. The WHOQOL group. Psychological Medicine, 28(3), 551–558.
We wish to thank all the patients who made this study possible.
This work was funded by the Center for Psychology at the University of Porto, Portuguese Science Foundation (FCT UID/PSI/00050/2019).
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Reis, A., Lencastre, L., Jonsson, C. et al. Treatment Adherence, Meaning in Life and Affects in Quality of Life of HIV/AIDS Patients. J Happiness Stud 21, 2405–2417 (2020). https://doi.org/10.1007/s10902-019-00182-y
- Quality of life
- Treatment adherence
- Meaning in life
- Affect balance HIV/AIDS