Hepatitis B virus (HBV) infection is an infectious disease that is specific to the liver, causing both acute and chronic hepatitis. This study determined the trend of HBV infection among blood donors in the Kpandai District Hospital from January 2014 to December 2018. Retrospective analysis of donor profiles for a period of 5 years was used to assess the distribution of seropositive cases in relation to age, sex, and trend. The data was collected using pre-designed questionnaire and managed using Microsoft Excel spread sheet 2013. The overall sero-prevalence of HBV was 8.2% (230/2802). The year to year analysis depicted significant trends in reduction of HBV infection among the study population at a rate of 13 percentage points above the mean from 2014 to 2015, and 4.3 percentage points below the mean from 2016 to 2018 across the period. The prevalence in males was 8.4% (225/2687) and that of the females was 4.4% (5/115) and the highest rate of infection was among those below 30 years 9.8% (163/1666). Although the general prevalence of HBV infection was high (8.2%), there was a significant trend reduction in rate of infection across the study period. This suggests that the public health interventional strategies put in place to manage the HBV infection in Kpandai District seem to be working.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
World Health Organization. (2017). Global hepatitis report 2017. Geneva: WHO; 2017. Contract No: Licence: CC BY-NC-SA, 3
Dongdem, J. T., Kampo, S., Soyiri, I. N., Asebga, P. N., Ziem, J. B., & Sagoe, K. (2012). Prevalence of Hepatitis B virus infection among blood donors at the Tamale Teaching Hospital, Ghana (2009). BMC Research Notes,5(1), 115.
World Health Organization. (2010). Screening donated blood for transfusion-transmissible infections: Recommendations. Geneva: World Health Organization.
World Health Organization. (2018). Facts sheets. World Health Organization Web Site. Retrieved from https://www.who.int/news-room/facts-sheets/detail/hepatitis-b
Olawumi Hannah Oluwayemisi, S. A. O., & Adenike, D. I. (2017). Prevalence and Trend of HBsAg, Anti-HCV and Anti-HIV among Blood Donors in a Tertiary Hospital in North Central Nigeria. SMU Medical Journal,4(1).
Nwobegahay, J. M., Njukeng, P. A., Kengne, M., Ayangma, C. R., Abeng, E. M., Nkeza, A., et al. (2016). Prevalence of Hepatitis B virus infection among blood donors at the Yaounde Military Hospital, Cameroon. Micro Res In,4(2), 6–10.
Shah, M., Shah, S., Gajjar, M., Bhatnagar, N., Soni, S., & Patel, V. (2016). Prevalence of HIV-I/II, HCV, HBsAg & syphilis in blood donors of western region In India. National Journal Integrative Research Medicine,7(1), 12–15.
Onoja, A., Orkuma, A., Nwannadi, I., Ejele, A., Egesie, O., Onoja, A., & Ibrahim, I. (2016). Seroepidemiology of hepatitis B, C & HIV among blood donors in Jos, north-central Nigeria. British Journal of Haematology, 173
WHO (2015). World health statistics 2015. World Health Organization; 2015 May 14.
Luuse, A., Dassah, S., Lokpo, S., Ameke, L., Noagbe, M., Adatara, P., et al. (2016). Sero-prevalence of Hepatitis B surface antigen amongst pregnant women attending an antenatal clinic, Volta region, Ghana. JOPHA,7(2), 584.
Ofori-Asenso, R., & Agyeman, A. A. (2016). Hepatitis B in Ghana: A systematic review & meta-analysis of prevalence studies (1995–2015). BMC Infectious Diseases,16(1). https://doi.org/10.1186/s12879-016-1467-5.
Nkrumah, B., Owusu, M., Frempong, H. O., & Averu, P. (2011). Hepatitis B and C viral infections among blood donors from rural Ghana. GMJ,45(3), 97.
Osei, E., Lokpo, S. Y., & Agboli, E. (2017). Sero-prevalence of hepatitis B infection among blood donors in a secondary care hospital, Ghana (2014): A retrospective analysis. BMC Research Notes,10(1), 391.
Okwesili, A., Usman, I., Abubakar, W., Onuigue, F., Erhabor, O. B., Hauwa, A. Y., et al. (2014). Prevalence of transfusion—Transmissible Hepatitis B infection among blood donors in Sokoto, North Western, Nigeria. Health Science Research,1, 4.
Prasad, B. V. S., Faheem, K., Anuradha, B., Lakshmi, A. V., Sushma, C., Sujatha, C., et al. (2018). Trend in seroprevalence of Hepatitis B virus infection among blood donors in a tertiary care teaching hospital In Tirupati. Journal of Infection in Developing Countries,17(5), 29–33. https://doi.org/10.9790/0853-1705032933.
Ampofo, W., Nii-Trebi, N., Ansah, J., Abe, K., Naito, H., Aidoo, S., et al. (2002). Prevalence of blood-borne infectious diseases in blood donors in Ghana. Journal of Clinical Microbiology,40(9), 3523–3525.
Walana, W., Ahiaba, S, Hokey, P., Vicar, E. K., Acquah, S. E. K., Der, E. M., & Ziem, J. B. (2014). Sero-prevalence of HIV, HBV and HCV among blood donors in the Kintampo Municipal Hospital, Ghana. Retrieved April 1, 2020, from www.uds.edu.gh.
Tanko, R., Mohamed, M., Kwaku, K., & Elliot, E. (2014). Short communication The prevalence of hepatitis B virus E antigen among Ghanaian blood donors. Pan African Medical Journal,8688, 1–4. https://doi.org/10.11604/pamj.2014.17.53.3390.
Fasola, F. A., Fadimu, P. A., & Akpan, V. O. (2017). A seven year review of the seroprevalence of transfusion transmitted infections in a hospital based blood bank in Ibadan, Nigeria. Clinical Medicine Research,6(1), 1. https://doi.org/10.11648/J.CMR.20170601.11.
Mohammed, Y., & Bekele, A. (2016). Seroprevalence of transfusion transmitted infection among blood donors at Jijiga blood bank, eastern Ethiopia: retrospective 4 years study. BMC Research Notes. https://doi.org/10.1186/s13104-016-1925-6.
Matee, M. I., Magesa, P. M., & Lyamuya, E. F. (2006). Seroprevalence of human immunodeficiency virus, Hepatitis B and C viruses and syphilis infections among blood donors at the Muhimbili National Hospital in Dar es Salaam, Tanzania. BMC Public Health,6(1), 21.
Romanò, L., Velati, C., Cambiè, G., Fomiatti, L., Galli, C., Zanetti, A. R., et al. (2013). Hepatitis B virus infection among first-time blood donors in Italy: Prevalence and correlates between serological patterns and occult infection. Blood Transfusion,11(2), 281.
Howell, J., Lemoine, M., & Thursz, M. (2014). Prevention of materno-foetal transmission of hepatitis B in sub-Saharan Africa: The evidence, current practice and future challenges. Journal of Viral Hepatitis,21(6), 381–396.
Yadav, B. S., Varma, A. V., Singh, P., Kumar, R., & Bandi, P. K. (2016). Seroprevalence of Transfusion-transmitted infections (TTIs) in blood donors: A study from Central India. International Journal of Medical Science and Public Health,5(6), 1–5.
Arya, D. R., Mahawar, N. L., Pachaury, R., Bharti, A., Sharma, L., Kumar, H., et al. (2016). Seroprevalence of transfusion transmitted infections among blood donors at a Tertiary Care Hospital Blood Bank in North India. Indian Journal of Health Sciences and Biomedical Research. https://doi.org/10.4103/2349-5006.183695.
Lokpo, S. Y., Dakorah, M. P., Norgbe, G. K., Osei-Yeboah, J., Adzakpah, G., Sarsah, I., et al. (2017). The burden and trend of blood-borne pathogens among asymptomatic adult population in Akwatia: A retrospective study at the St. Dominic Hospital, Ghana. Journal of Tropical Medicine. https://doi.org/10.1155/2017/3452513.
Lokpo, S. Y., Osei-Yeboah, J., Norgbe, G. K., Owiafe, P. K., Ayroe, F., Ussher, F. A., et al. (2017). Viral hepatitis endemicity and trends among an asymptomatic adult population in Ho: A 5-year retrospective study at the Ho municipal hospital Ghana. Hepatitis Research and Treatment. https://doi.org/10.1155/2017/6174743.
Yang, F., Yin, Y., Wang, F., Zhang, L., Wang, Y., & Sun, S. (2009). An altered pattern of liver apolipoprotein AI isoforms is implicated in male chronic hepatitis B progression. Journal of Proteome Research,9(1), 134–143.
Mitchell, K. R., Mercer, C. H., Prah, P., Clifton, S., Tanton, C., Wellings, K., et al. (2019). Why do men report more opposite-sex sexual partners than women? Analysis of the gender discrepancy in a British national probability survey. The Journal Sex Research,56(1), 1–8.
Abate, M., & Wolde, T. (2016). Seroprevalence of human immunodeficiency virus, Hepatitis B virus, Hepatitis C virus, and syphilis among blood donors at Jigjiga blood bank, eastern Ethiopia. Ethiopian Journal of Health Science,26(2), 155–162.
Liu, J., Zhang, S., Liu, M., Wang, Q., Shen, H., & Zhang, Y. (2018). Distribution of ABO/Rh blood groups and their association with Hepatitis B virus infection in 3.8 million Chinese adults: A population-based cross-sectional study. Journal of Viral Hepatitis,25(4), 401–411.
Lao, T. T., Sahota, D. S., Chung, M. K., Cheung, T. K. W., Cheng, Y. K. Y., & Leung, T. Y. (2014). Maternal ABO and rhesus blood group phenotypes and Hepatitis B surface antigen carriage. Journal of Viral Hepatitis,21(11), 818–823.
We express our appreciation to the Blood bank of Kpandai District Hospital for giving us access to the data used for the study.
Conflict of interest
The authors declare that they have no conflict of interest.
The protocol used for the study was approved by the University of Health and Allied Sciences’ Research Ethical Committee (Protocol Number: UHAS-REC/A.4  18-19).
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Electronic supplementary material
Below is the link to the electronic supplementary material.
About this article
Cite this article
Bawah, A.T., Kinanyok, S., Abaka-Yawson, A. et al. Seroprevalence of Hepatitis B Infection Among a Population of Blood Donors in the Kpandai District of Northern Ghana: A Five-Year Retrospective Study from 2014 to 2018. J Community Health (2020). https://doi.org/10.1007/s10900-020-00862-4
- Hepatitis B virus
- Blood donors