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How Can Psychological Science Inform Research About Genetic Counseling for Clinical Genomic Sequencing?

  • PROFESSIONAL ISSUES
  • Published:
Journal of Genetic Counseling

An Erratum to this article was published on 25 December 2014

Abstract

Next generation genomic sequencing technologies (including whole genome or whole exome sequencing) are being increasingly applied to clinical care. Yet, the breadth and complexity of sequencing information raise questions about how best to communicate and return sequencing information to patients and families in ways that facilitate comprehension and optimal health decisions. Obtaining answers to such questions will require multidisciplinary research. In this paper, we focus on how psychological science research can address questions related to clinical genomic sequencing by explaining emotional, cognitive, and behavioral processes in response to different types of genomic sequencing information (e.g., diagnostic results and incidental findings). We highlight examples of psychological science that can be applied to genetic counseling research to inform the following questions: (1) What factors influence patients’ and providers’ informational needs for developing an accurate understanding of what genomic sequencing results do and do not mean?; (2) How and by whom should genomic sequencing results be communicated to patients and their family members?; and (3) How do patients and their families respond to uncertainties related to genomic information?

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All of the authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Health Behavior, University of North Carolina-Chapel Hill, 312 Rosenau Hall, CB#7440, Chapel Hill, NC, 27599-7440, USA

    Cynthia M. Khan

  2. Health Behavior, Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA

    Christine Rini

  3. Translational Medicine and Human Genetics, University of Pennsylvania, Philadelphia, PA, USA

    Barbara A. Bernhardt

  4. Health Behavior & Health Education, Center for Bioethics and Social Sciences in Medicine, University of Michigan-Ann Arbor, Ann Arbor, MI, USA

    J. Scott Roberts

  5. Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

    Kurt D. Christensen

  6. Genetics, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA

    James P. Evans, Myra I. Roche & Jonathan S. Berg

  7. Family and Geriatric Medicine, University of Louisville School of Medicine, Louisville, KY, USA

    Kyle B. Brothers

  8. Pediatrics, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA

    Myra I. Roche

  9. Social Medicine, Center for Genomics & Society, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA

    Gail E. Henderson

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  1. Cynthia M. Khan
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  2. Christine Rini
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  10. Gail E. Henderson
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Correspondence to Cynthia M. Khan.

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Khan, C.M., Rini, C., Bernhardt, B.A. et al. How Can Psychological Science Inform Research About Genetic Counseling for Clinical Genomic Sequencing?. J Genet Counsel 24, 193–204 (2015). https://doi.org/10.1007/s10897-014-9804-6

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