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Journal of Genetic Counseling

, Volume 24, Issue 2, pp 193–204 | Cite as

How Can Psychological Science Inform Research About Genetic Counseling for Clinical Genomic Sequencing?

  • Cynthia M. KhanEmail author
  • Christine Rini
  • Barbara A. Bernhardt
  • J. Scott Roberts
  • Kurt D. Christensen
  • James P. Evans
  • Kyle B. Brothers
  • Myra I. Roche
  • Jonathan S. Berg
  • Gail E. Henderson
PROFESSIONAL ISSUES

Abstract

Next generation genomic sequencing technologies (including whole genome or whole exome sequencing) are being increasingly applied to clinical care. Yet, the breadth and complexity of sequencing information raise questions about how best to communicate and return sequencing information to patients and families in ways that facilitate comprehension and optimal health decisions. Obtaining answers to such questions will require multidisciplinary research. In this paper, we focus on how psychological science research can address questions related to clinical genomic sequencing by explaining emotional, cognitive, and behavioral processes in response to different types of genomic sequencing information (e.g., diagnostic results and incidental findings). We highlight examples of psychological science that can be applied to genetic counseling research to inform the following questions: (1) What factors influence patients’ and providers’ informational needs for developing an accurate understanding of what genomic sequencing results do and do not mean?; (2) How and by whom should genomic sequencing results be communicated to patients and their family members?; and (3) How do patients and their families respond to uncertainties related to genomic information?

Keywords

Communication Genome sequencing Patient understanding Psychological Psychosocial 

Notes

Conflict of Interest

All of the authors declare that they have no conflict of interest.

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Copyright information

© National Society of Genetic Counselors, Inc. 2014

Authors and Affiliations

  • Cynthia M. Khan
    • 1
    Email author
  • Christine Rini
    • 2
  • Barbara A. Bernhardt
    • 3
  • J. Scott Roberts
    • 4
  • Kurt D. Christensen
    • 5
  • James P. Evans
    • 6
  • Kyle B. Brothers
    • 7
  • Myra I. Roche
    • 6
    • 8
  • Jonathan S. Berg
    • 6
  • Gail E. Henderson
    • 9
  1. 1.Department of Health BehaviorUniversity of North Carolina-Chapel HillChapel HillUSA
  2. 2.Health Behavior, Lineberger Comprehensive Cancer CenterUniversity of North Carolina-Chapel HillChapel HillUSA
  3. 3.Translational Medicine and Human GeneticsUniversity of PennsylvaniaPhiladelphiaUSA
  4. 4.Health Behavior & Health Education, Center for Bioethics and Social Sciences in MedicineUniversity of Michigan-Ann ArborAnn ArborUSA
  5. 5.Genetics, Department of MedicineBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA
  6. 6.GeneticsUniversity of North Carolina-Chapel HillChapel HillUSA
  7. 7.Family and Geriatric MedicineUniversity of Louisville School of MedicineLouisvilleUSA
  8. 8.PediatricsUniversity of North Carolina-Chapel HillChapel HillUSA
  9. 9.Social Medicine, Center for Genomics & SocietyUniversity of North Carolina-Chapel HillChapel HillUSA

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