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N-Doped Carbon Dots as a Fluorescent Nanosensor for Determination of Colchicine Based on Inner Filter Effect

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Abstract

In this study, a novel and simple fluorescent carbon quantum dots (CQDs) based nano-sensor for colchicine determination has been prepared. The nitrogen doped CQDs probe was prepared using uric acid as a carbon/nitrogen source via a one-step pyrolysis. The sensor is based on inner filter effect (IFE) where colchicine acts as a powerful absorber that affects the excitation of the fluorescer (CQDs). This overlap results in a quantitative attenuation of the fluorescence of CQDs with increasing colchicine concentration in the range of 2–25 μM. The developed sensor has the advantages of simplicity, less time-consuming, convenience and satisfactory selectivity for colchicine determination in pharmaceutical dosage forms.

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Authors and Affiliations

  1. Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt

    Samah F. El-Malla, Eman A. Elshenawy, Sherin F. Hammad & Fotouh R. Mansour

  2. Pharmaceutical Services Center, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt

    Fotouh R. Mansour

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  1. Samah F. El-Malla
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Contributions

Conceptualization: [Samah F. El-Malla], [Eman A. Elshenawy], [Sherin F. Hammad], [Fotouh R. Mansour]; Formal analysis [Samah F. El-Malla], [Eman A. Elshenawy], [Sherin F. Hammad], [Fotouh R. Mansour]; Investigation: [Eman A. Elshenawy]; Writing - original draft: [Eman A. Elshenawy]; Writing - review and editing: [Samah F. El-Malla], [Sherin F. Hammad], [Fotouh R. Mansour]. The author(s) read and approved the final manuscript.

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Correspondence to Eman A. Elshenawy.

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El-Malla, S.F., Elshenawy, E.A., Hammad, S.F. et al. N-Doped Carbon Dots as a Fluorescent Nanosensor for Determination of Colchicine Based on Inner Filter Effect. J Fluoresc 31, 675–684 (2021). https://doi.org/10.1007/s10895-021-02698-0

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