Stepwise Assembly Protocols for the Rational Design of Lanthanide Functionalized Carbon Dots-Hydrogel and its Sensing Evaluation

Abstract

Inorganic-organic optical probe based on lanthanide emission will provide a new way for specific applications. In this work, sarcosine and urea are selected as raw materials to synthesize carbon dots with cyan-emissive color. In the next step, indicator components (Ethylene Diamine Tetraacetic Acid and lanthanide ions) are incorporated onto carbon quantum dots (CQDs) and the flexible alginate hydrogel is employed as the host to accommodate the emissive species. The soft material can exhibit typical red and green emissions. Its luminescence is responsive to calcium ions and the detection limit has been calculated to be 0.84 μM and 0.92 μM respectively. Such optical device can be employed as a portable probe in a variety of scientific fields due to its convenience and flexibility.

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References

  1. 1.

    Qin M, Sun M, Bai R, Mao Y, Qian X, Sikka D, Zhao Y, Qi HJ, Suo Z, He X (2018) Bioinspired Hydrogel Interferometer for Adaptive Coloration and Chemical Sensing. Adv Mater 30(21):e1800468. https://doi.org/10.1002/adma.201800468

    CAS  Article  PubMed  Google Scholar 

  2. 2.

    Fu X, Wang P, Miao Q, Liu K, Liu H, Liu J, Fang Y (2016) Polymerizable organo-gelator-stabilized gel-emulsions toward the preparation of compressible porous polymeric monoliths. J Mater Chem A 4(39):15215–15223. https://doi.org/10.1039/c6ta05070k

    CAS  Article  Google Scholar 

  3. 3.

    Liu S, Ling J, Li K, Yao F, Oderinde O, Zhang Z, Fu G (2017) Bio-inspired and lanthanide-induced hierarchical sodium alginate/graphene oxide composite paper with enhanced physicochemical properties. Compos Sci Technol 145:62–70. https://doi.org/10.1016/j.compscitech.2017.01.009

    CAS  Article  Google Scholar 

  4. 4.

    Podder D, Nandi SK, Sasmal S, Haldar D (2019) Synergistic Tricolor Emission-Based White Light from Supramolecular Organic-Inorganic Hybrid Gel. Langmuir 35(19):6453–6459. https://doi.org/10.1021/acs.langmuir.9b00456

    CAS  Article  PubMed  Google Scholar 

  5. 5.

    Mohamed AK, Mahmoud ME (2020) Encapsulation of starch hydrogel and doping nanomagnetite onto metal-organic frameworks for efficient removal of fluvastatin antibiotic from water. Carbohydr Polym 245:116438. https://doi.org/10.1016/j.carbpol.2020.116438

    CAS  Article  PubMed  Google Scholar 

  6. 6.

    Heo G, Son K, Jeong YH, Kim CG, Do JY (2017) Development of 1,2- and 1,3-Ketohydrazones Derived Rhodamine Chromophores Sensitive to Metal Ions and pH. J Nanosci Nanotechnol 17(8):5652–5655. https://doi.org/10.1166/jnn.2017.14116

    CAS  Article  Google Scholar 

  7. 7.

    Kim JU, Kim YK, Yang H (2010) Reverse micelle-derived Cu-doped Zn(1-x)Cd(x)S quantum dots and their core/shell structure. J Colloid Interface Sci 341(1):59–63. https://doi.org/10.1016/j.jcis.2009.09.039

    CAS  Article  PubMed  Google Scholar 

  8. 8.

    Ye S, Xiao F, Pan YX, Ma YY, Zhang QY (2010) Phosphors in phosphor-converted white light-emitting diodes: Recent advances in materials, techniques and properties. Mater Sci Eng R 71(1):1–34. https://doi.org/10.1016/j.mser.2010.07.001

    CAS  Article  Google Scholar 

  9. 9.

    Wang F, Chen P, Feng Y, Xie Z, Liu Y, Su Y, Zhang Q, Wang Y, Yao K, Lv W, Liu G (2017) Facile synthesis of N-doped carbon dots/g-C3N4 photocatalyst with enhanced visible-light photocatalytic activity for the degradation of indomethacin. Appl Catal B 207:103–113. https://doi.org/10.1016/j.apcatb.2017.02.024

    CAS  Article  Google Scholar 

  10. 10.

    Qiao G, Chen G, Wen Q, Liu W, Gao J, Yu Z, Wang Q (2020) Rapid conversion from common precursors to carbon dots in large scale: Spectral controls, optical sensing, cellular imaging and LEDs application. J Colloid Interf Sci 580:88–98. https://doi.org/10.1016/j.jcis.2020.07.034

    CAS  Article  Google Scholar 

  11. 11.

    Genc R, Alas MO, Harputlu E, Repp S, Kremer N, Castellano M, Colak SG, Ocakoglu K, Erdem E (2017) High-Capacitance Hybrid Supercapacitor Based on Multi-Colored Fluorescent Carbon-Dots. Sci Rep 7(1):11222. https://doi.org/10.1038/s41598-017-11347-1

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  12. 12.

    Konar S, Kumar BNP, Mahto MK, Samanta D, Shaik MAS, Shaw M, Mandal M, Pathak A (2019) N-doped carbon dot as fluorescent probe for detection of cysteamine and multicolor cell imaging. Sensor Actuat B: Chem 286:77–85. https://doi.org/10.1016/j.snb.2019.01.117

    CAS  Article  Google Scholar 

  13. 13.

    Ma H, Sun C, Xue G, Wu G, Zhang X, Han X, Qi X, Lv X, Sun H, Zhang J (2019) Facile synthesis of fluorescent carbon dots from Prunus cerasifera fruits for fluorescent ink, Fe(3+) ion detection and cell imaging. Spectrochim Acta A 213:281–287. https://doi.org/10.1016/j.saa.2019.01.079

    CAS  Article  Google Scholar 

  14. 14.

    Liu Y, Yang H, Ma C, Luo S, Xu M, Wu Z, Li W, Liu S (2020) Luminescent Transparent Wood Based on Lignin-Derived Carbon Dots as a Building Material for Dual-Channel, Real-Time, and Visual Detection of Formaldehyde Gas. ACS Appl Mater Interf 12(32):36628–36638. https://doi.org/10.1021/acsami.0c10240

    CAS  Article  Google Scholar 

  15. 15.

    Dong H, Du S-R, Zheng X-Y, Lyu G-M, Sun L-D, Li L-D, Zhang P-Z, Zhang C, Yan C-H (2015) Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy. Chem Rev 115(19):10725–10815. https://doi.org/10.1021/acs.chemrev.5b00091

    CAS  Article  PubMed  Google Scholar 

  16. 16.

    Wu S, Lin Y, Liu J, Shi W, Yang G, Cheng P (2018) Rapid Detection of the Biomarkers for Carcinoid Tumors by a Water Stable Luminescent Lanthanide Metal-Organic Framework Sensor. Adv Funct Mater 28(17). https://doi.org/10.1002/adfm.201707169

  17. 17.

    Wang F, Liu X (2014) Multicolor tuning of lanthanide-doped nanoparticles by single wavelength excitation. Acc Chem Res 47(4):1378–1385. https://doi.org/10.1021/ar5000067

    CAS  Article  PubMed  Google Scholar 

  18. 18.

    Wang H, Ke F, Mararenko A, Wei Z, Banerjee P, Zhou S (2014) Responsive polymer-fluorescent carbon nanoparticle hybrid nanogels for optical temperature sensing, near-infrared light-responsive drug release, and tumor cell imaging. Nanoscale 6(13):7443–7452. https://doi.org/10.1039/c4nr01030b

    CAS  Article  PubMed  Google Scholar 

  19. 19.

    Drury JL, Mooney DJ (2003) Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials 24(24):4337–4351. https://doi.org/10.1016/s0142-9612(03)00340-5

    CAS  Article  PubMed  Google Scholar 

  20. 20.

    Lee KY, Mooney DJ (2012) Alginate: properties and biomedical applications. Prog Polym Sci 37(1):106–126. https://doi.org/10.1016/j.progpolymsci.2011.06.003

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  21. 21.

    Peppas NA, Hilt JZ, Khademhosseini A, Langer R (2006) Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology. Adv Mater 18(11):1345–1360. https://doi.org/10.1002/adma.200501612

    CAS  Article  Google Scholar 

  22. 22.

    Slaughter BV, Khurshid SS, Fisher OZ, Khademhosseini A, Peppas NA (2009) Hydrogels in regenerative medicine. Adv Mater 21(32–33):3307–3329. https://doi.org/10.1002/adma.200802106

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  23. 23.

    Ma Q, Wang Q (2015) Lanthanide induced formation of novel luminescent alginate hydrogels and detection features. Carbohydr Polym 133:19–23. https://doi.org/10.1016/j.carbpol.2015.07.017

    CAS  Article  PubMed  Google Scholar 

  24. 24.

    Zhou Z, Li XQ, Tang YP, Zhang CC, Fu HR, Wu NT, Ma LF, Gao JW, Wang QM (2018) Oxidative deoximation reaction induced recognition of hypochlorite based on a new fluorescent lanthanide-organic framework. Chem Eng J 351:364–370. https://doi.org/10.1016/j.cej.2018.06.123

    CAS  Article  Google Scholar 

  25. 25.

    Li XQ, Gu JP, Zhou Z, Ma LF, Tang YP, Gao JW, Wang QM (2019) New lanthanide ternary complex system in electrospun nanofibers: Assembly, physico-chemical property and sensor application. Chem Eng J 358:67–73. https://doi.org/10.1016/j.cej.2018.10.003

    CAS  Article  Google Scholar 

  26. 26.

    Liu XY, Gao JW, Zhou GF, Liu WQ, Wang QM, Zheng YH (2020) Low molecular weight molecule induces the effective stabilization of CsPbBr3 in water. J Mol Liq 299:112199. https://doi.org/10.1016/j.molliq.2019.112199

    CAS  Article  Google Scholar 

  27. 27.

    Caffrey DF, Gunnlaugsson T (2014) Displacement assay detection by a dimeric lanthanide luminescent ternary Tb(III)-cyclen complex: high selectivity for phosphate and nitrate anions. Dalton Trans. 43:17964–17970. https://doi.org/10.1039/C4DT02341B

    CAS  Article  PubMed  Google Scholar 

  28. 28.

    Qiao GX, Liu L, Hao XX, Zheng JK, Liu WQ, Gao JW, Zhang CC, Wang QM (2020) Signal transduction from small particles: Sulfur nanodots featuring mercury sensing, cell entry mechanism and in vitro tracking performance. Chem Eng J 382:122907. https://doi.org/10.1016/j.cej.2019.122907

    CAS  Article  Google Scholar 

  29. 29.

    Zhou Z, Wang QM, Wang JY, Zhang CC (2015) Imaging two targets in live cells based on rational design of lanthanide organic structure appended carbon dots. Carbon 93:671–680. https://doi.org/10.1016/j.carbon.2015.05.107

    CAS  Article  Google Scholar 

  30. 30.

    Lakowicz JR (2006) Principles of Fluorescence Spectroscopy. Springer-Verlag Berlin Heidelberg.

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Funding

Q. M. appreciates the support from Science and Technology Plan of Guangdong Province (No. 2020A0505100055), Guangzhou Science and Technology Plan (No. 202002030325), Science and Technology Program of Guangzhou (No. 201905001) and Guangdong Provincial Key Laboratory of Optical Information Materials and Technology (No. 2017B030301007). Q. Wen thanks for the support from Innovation Project of Graduate School of South China Normal University (2019LKXM009).

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Qin Wen: Conceptualization, Investigation, Writing - original draft.

Yuhui Zheng: assisted with data collection and data analysis..

Wanqiang Liu: assisted with data collection and visualization.

Qianming Wang: Supervision, funding acquisition, writing and reviewing.

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Correspondence to Yuhui Zheng or Qianming Wang.

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Wen, Q., Zheng, Y., Liu, W. et al. Stepwise Assembly Protocols for the Rational Design of Lanthanide Functionalized Carbon Dots-Hydrogel and its Sensing Evaluation. J Fluoresc (2021). https://doi.org/10.1007/s10895-021-02694-4

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Keywords

  • Carbon quantum dots
  • Lanthanide
  • Calcium
  • Soft material