Two Metal Complexes: Selective Detection of Fe3+ Ion and Promotion Activity on Mesenchymal Stem Cells Differentiate Into Vascular Endothelial Cells

Abstract

With the aid of 1,2-bis(4-pyridyl)ethane (bpee), a nitrogen-donor ligand and 1,3,5-tris(carboxymethoxy)benzene (H3TCMB), a tripodal ether-connector tricarboxylate ligand, two novel transition metal coordination polymers (CPs) have been synthesized via the reaction of Zn(NO3)2·6H2O or Cu(NO3)2·3H2O with the ligands of H3TCMB and bpee ligands with similar reactions under slightly distinct temperatures (80℃ for 1 and 120℃ for 2), and their chemical formula are [Cu4(TCMB)2(bpee)23-OH)2(H2O)2]n·12nH2O (1) and [Zn4(TCMB)2(bpee)23-OH)2(H2O)2]n·12nH2O (2). Complex 2 can be utilized as a super sensitive fluorescence quenching sensor to determine the Fe3+ ions. The effect of these two compounds on the differentiation of mesenchymal stem cells (MSCs) into the cells of vascular endothelial was further explored.

This is a preview of subscription content, access via your institution.

Scheme 1
Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Data Availability

The data used to support the findings of this study are included within the article.

References

  1. 1.

    Han Y, Li X, Zhang Y, Han Y, Chang F, Ding J (2019) Mesenchymal stem cells for regenerative medicine. Cells 8:886

    CAS  Article  Google Scholar 

  2. 2.

    Li P, Gong Z, Shultz LD, Ren G (2019) Mesenchymal stem cells: From regeneration to cancer. Pharmacol Ther 200:42–54

    CAS  Article  Google Scholar 

  3. 3.

    Naji A, Eitoku M, Favier B, Deschaseaux F, Rouas-Freiss N, Suganuma N (2019) Biological functions of mesenchymal stem cells and clinical implications. Cell Mol Life Sci 76:3323–3348

    CAS  Article  Google Scholar 

  4. 4.

    Yuan D, Sun M, Zhao M, Tang S, Qi J, Zhang X, Wang K, Li B (2020) Persulfate promoted ZnIn2S4 visible light photocatalytic dye decomposition. Int J Electrochem Sci 15:8761–8770

    Article  Google Scholar 

  5. 5.

    Jiang N, Liu Y, Yu XN, Zhang HB, Wang MM (2020) Corrosion resistance of Nickel-Phosphorus/Nano-ZnO composite multilayer coating electrodeposited on carbon steel in acidic chloride environments. Int J Electrochem Sci 15:5520–5528

    CAS  Article  Google Scholar 

  6. 6.

    Li JX, Du ZX (2020) A binuclear cadmium(II) cluster based on π···π stacking and halogen···halogen interactions: synthesis, crystal analysis and fluorescent properties. J Clust Sci 31:507–511

    CAS  Article  Google Scholar 

  7. 7.

    Li JX, Du ZX, Feng X (2019) A new binuclear Ni(II) complex with tetrafluorophthalate and 2,2′-bipyridine ligands: synthesis, crystal structure and magnetic properties. Z Naturforsch 74:833–838

    CAS  Article  Google Scholar 

  8. 8.

    Li JX, Du ZX, Wang J, Feng X (2019) Two mononuclear zinc(II) complexes constructed by two types of phenoxyacetic acid ligands: syntheses, crystal structures and fluorescence properties. Z Naturforsch 74:839–845

    CAS  Article  Google Scholar 

  9. 9.

    Li JX, Du ZX (2016) Zinc and cobalt complexes with (2-carboxyphenoxy) acetic acid ligand: syntheses, structures, fluorescent and magnetic properties. J Coord Chem 69:2563–2572

    CAS  Article  Google Scholar 

  10. 10.

    Duan C, Su Z, Cao Y, Hu L, Fu D, Ma J, Zhang Y (2021) Synthesis of core-shell α-AlH3@Al(OH)3 nanocomposite with improved low-temperature dehydriding properties by mechanochemical mixing and ionic liquid treatment. J Clean Prod 283:124635

    CAS  Article  Google Scholar 

  11. 11.

    Liu JJ, Xia SB, Duan YL, Liu T, Cheng FX, Sun CK (2018) Anion-controlled architecture and photochromism of naphthalene diimide-based coordination polymers. Polymers (Basel) 10:165

    Article  Google Scholar 

  12. 12.

    Haldar R, Matsuda R, Kitagawa S, George SJ, Maji TK (2014) Amine-responsive adaptable nanospaces: Fluorescent porous coordination polymer for molecular recognition. Angew Chem Int Ed 53:11772–11777

    CAS  Article  Google Scholar 

  13. 13.

    Liu B, Wei L, Li NN, Wu WP, Miao H, Wang YY, Shi QZ (2014) Solvent/temperature and dipyridyl ligands induced diverse coordination polymers based on 3-(2′,5′-dicarboxylphenyl)pyridine. Cryst Growth Des 14:1110–1127

    CAS  Article  Google Scholar 

  14. 14.

    Wang K, Ma X, Shao D, Geng Z, Zhang Z, Wang Z (2012) Coordination-induced assembly of coordination polymer submicrospheres: promising antibacterial and in vitro anticancer activities. Cryst Growth Des 12:3786–3791

    CAS  Article  Google Scholar 

  15. 15.

    Zheng LN, Wei FH, Hu HM, Bai C, Yang XL, Wang X, Xue G (2019) Lanthanide coordination polymers constructed from the asymmetrical N-heterocyclic rigid carboxylate: Synthesis, crystal structures, luminescence properties and magnetic properties. Polyhedron 161:47–55

    CAS  Article  Google Scholar 

  16. 16.

    Zhang X, Hou L, Liu B, Cui L, Wang YY, Wu B (2013) Syntheses, structures, and luminescent properties of six new zinc(II) coordination polymers constructed by flexible tetracarboxylate and various pyridine ligands. Cryst Growth Des 13:3177–3187

    CAS  Article  Google Scholar 

  17. 17.

    Arici M, Yeşilel OZ, Taş M, Demiral H (2017) CO2 and iodine uptake properties of Co(II)-coordination polymer constructed from tetracarboxylic acid and flexible Bis(imidazole) linker. Cryst Growth Des 17:2654–2659

    CAS  Article  Google Scholar 

  18. 18.

    Mukherjee S, Ganguly S, Manna K, Mondal S, Mahapatra S, Das D (2018) Green approach to synthesize crystalline nanoscale Zn(II)-coordination polymers: cell growth inhibition and immunofluorescence study. Inorg Chem 57:4050–4060

    CAS  Article  Google Scholar 

  19. 19.

    Wu B, Zhang WH, Ren ZG, Lang JP (2015) A 1D anionic coordination polymer showing superior Congo Red sorption and its dye composite exhibiting remarkably enhanced photocurrent response. Chem Commun 51:14893–14896

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Contributions

Qin-Ming Zhao and Zhong-You Xu synthesized and characterized the compounds; Hui-Peng Zhu and Yu-Xiang He performed the activity assay experiments; Mo Wang designed the study and prepared the manuscript.

Corresponding author

Correspondence to Qin-Ming Zhao.

Ethics declarations

Conflict of Interest

The author(s) declare(s) that there is no conflict of interest regarding the publication of this paper.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Zhao, QM., Xu, ZY., Zhu, HP. et al. Two Metal Complexes: Selective Detection of Fe3+ Ion and Promotion Activity on Mesenchymal Stem Cells Differentiate Into Vascular Endothelial Cells. J Fluoresc (2021). https://doi.org/10.1007/s10895-021-02693-5

Download citation

Keywords

  • Coordination polymer
  • Fluorescence quenching
  • Mesenchymal stem cells
  • Vascular endothelial growth factor