Journal of Fluorescence

, Volume 26, Issue 1, pp 177–187 | Cite as

Symmetric Meso-Chloro-Substituted Pentamethine Cyanine Dyes Containing Benzothiazolyl/Benzoselenazolyl Chromophores Novel Synthetic Approach and Studies on Photophysical Properties upon Interaction with bio-Objects



A series of symmetric pentamethine cyanine dyes derived from various N-substituted benzothiazolium/benzoselenazolium salts, and a conjugated bis-aniline derivative containing a chlorine atom at meso-position with respect to the polymethine chain, were synthesized using a novel improved synthetic approach under mild conditions at room temperature. The reaction procedure was held by grinding the starting compounds for relative short times. The novel method is reliable and highly reproducible. Some photophysical characteristics were recorded in various solvents, including absorption, and fluorescence quantum yields using Cy-5 as a reference. Additional studies on interactions with several bio-objects such as liposomes, DNA, and proteins have been investigated in the present work.


Pentamethine cyanine dyes 2-methylbenzothiazole 2-methylbenzoselenazole Fluorescent markers Liposomes DNA, proteins H-aggregates 


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Atanas Kurutos
    • 1
  • Olga Ryzhova
    • 2
  • Valeriya Trusova
    • 2
    • 3
  • Galyna Gorbenko
    • 2
  • Nikolay Gadjev
    • 1
  • Todor Deligeorgiev
    • 1
  1. 1.Sofia University “St. Kliment Ohridski”Faculty of Chemistry and PharmacySofiaBulgaria
  2. 2.Department of Nuclear and Medical PhysicsV.N. Karazin Kharkiv National UniversityKharkivUkraine
  3. 3.19-32 Geroyev TrudaKharkivUkraine

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