Abstract
A new water-soluble surfactant copper(II) complex [Cu(sal-ala)(phen)(DA)] (sal-ala = salicylalanine, phen = 1,10-phenanthroline, DA = dodecylamine), has been synthesized and characterized by physico-chemical and spectroscopic methods. The critical micelle concentration (CMC) values of this surfactant–copper(II) complex in aqueous solution were obtained from conductance measurements. Specific conductivity data (at 303, 308, 313. 318 and 323 K) served for the evaluation of the temperature-dependent CMC and the thermodynamics of micellization (ΔG0m, ΔH0m and ΔS0m). The interaction of this complex with nucleic acids (DNA and RNA) has been explored by using electronic absorption spectral titration, competitive binding experiment, cyclic voltammetry, circular dichroism (CD) spectra, and viscosity measurements. Electronic absorption studies have revealed that the complex can bind to nucleic acids by the intercalative binding mode which has been verified by viscosity measurements. The DNA binding constants have also been calculated (Kb = 1.2 × 105 M−1 for DNA and Kb = 1.6 × 105 M−1 for RNA). Competitive binding study with ethidium bromide (EB) showed that the complex exhibits the ability to displace the DNA-bound-EB indicating that the complex binds to DNA in strong competition with EB for the intercalative binding site. The presence of hydrophobic ligands, alanine Schiff-base, phenanthroline and long aliphatic chain amine in the complex were responsible for this strong intercalative binding. The surfactant–copper (II) complex was screened for its antibacterial and antifungal activities against various microorganisms. The results were compared with the standard drugs, amikacin(antibacterial) and ketokonazole(antifungal).
Similar content being viewed by others
References
Souza P, Garcia-Vazquez JA, Masaguer JR (1985) Trans Met Chem 10:410–412
Sunaga SAS, Taniguchi T, Miyazaki H, Nabeshima T (2007) Inorg Chem 46:2959–2961
Quiroga AG, Ranninger CN (2004) Coord Chem Rev 248:119–133
Elerman Y, Kabak M, Elmali A (2002) Z Naturforsch B 57:651–656
Bhattacharya S, Mandal SS (1997) Biochim Biophys Acta 1323:29–44
Hermann T (2005) Curr Opin Struct Biol 15:355–366
Thomas JR, Hergenrother PJ (2008) Chem Rev 108:1171–1224
Ni Y, Li D, Kokot S (2006) Anal Biochem 352:31–242
Chow CS, Barton JK (1992) Biochemistry 31:5423–5429
Kashanian S, Gholivand MB, Ahmadi F et al (2007) Spectrochim Acta A 67:472–478
Uma V, Kanthimathi M, Weyhermuller T, Nair BUJ (2005) Inorg Biochem 99:2299–2307
Trewavas A (1967) Anal Biochem 21:324–329
Haifz AA (2005) J Surfactant Deterg 8:359–363
Kumaraguru N, Santhakumar K, Arunachalam S, Arumugam MN (2007) Int J Chem Kinet 39:22–28
Arumugam MN, Santhakumar K, Kumaraguru N, Arunachalam S (2003) Asian J Chem 15:191–196
Santhakumar K, Kumaraguru N, Arumugam MN, Arunachalam S (2006) Polyhedron 25:1507–1513
Ndifon TP, Moise OA, Julius NN, Mbom DY, Awawou GP, Lynda DN (2010) Res J Chem Environ 14:50–54
Shedlovsky T (1932) J Am Chem Soc 54:411–1428
Reichmann MF, Rice SA, Thomas CA, Doty P (1954) J Am Chem Soc 76:3047–3053
Dunn TM (1960) The visible and ultraviolet spectra of complex compounds in modern coordination chemistry. Interscience, New York
Garcia-Raso A (1999) Polyhedron 18:871–878
Tadros TF (2005) Applied surfactants, 1st edn. Wiley-VCH, Weinheim
Morris ML, Busch DH (1960) J Am Chem Soc 82:1521–1524
Strukl JS, Walter JL (1971) Spectrochim Acta A 27:223–238
Schilt AA, Taylor RC (1959) J Inorg Nuc Chem 9:211–221
Speie G, Csihony J, Whalen AM, Pie CG (1996) Inorg Chem 35:3519–3524
Gonzalez-Perez A, Del Castillo JL, Czapkiewicz J, Rodriguez JR (2004) Colloids Surf A Physicochem Eng Asp 232:183–189
Zana RJ (1980) Colloid Interf Sci 78:330–337
Nusselder JJH, Engberts JBFN (1992) J Colloid Interf Sci 148:353–361
Kumaraguru N, Arunachalam S, Arumugam MN, Santhakumar K (2006) Trans Met Chem 31:250–255
Warring MJ (1965) J Mol Biol 13:269–282
Cantor C, Schimmel PR (1980) Biophy Chem Freeman WH, San Francisco, 2:398
Pyle AM, Rehmann JP, Meshoyrer R, Kumar CV, Turro NJ, Barton JK (1989) J Am Chem Soc 111:3051–3058
Carter MT, Rodriguez M, Bard AJ (1989) J Am Chem Soc 111:8901–8911
Tamil Selvi P, Palaniandavar M (2002) Inorg Chim Acta 337:420–428
Zhao G, Lin H, Zhu S, Sun H, Chen Y (1998) J Inorg Biochem 70:219–226
Lakowicz JR, Webber G (1973) Biochemistry 12:4161–4170
Shen Q, Liu J, Chao H, Xue G, Ji L (2001) J Inorg Biochem 83:49–55
Satyanaryana S, Daborusak JC, Chaires JB (1992) Biochemistry 31:9319–9324
Uma Maheswari P, Palaniandavar M (2004) J Inorg Biochem 98:219–230
Lincoln P, Tuite E, Norden B (1997) J Am Chem Soc 119:1454–1455
Ivanov VI, Minchenkova LE, Shchelkina AK, Poletaev AI (1973) Biopolymers 12:89–110
Satyanaryana S, Daborusak JC, Chaires JB (1993) Biochemistry 32:2573–2584
Garcia-Raso A, Fiol JJ, Zafra AL, Mata I, Espinosa E, Molins E (2000) Polyhedron 19:673–680
Nyholm RS, Tobe ML (1956) J Chem Soc 1707–1718
Buckingham DA, Jones D (1965) Inorg Chem 4:1387–1392
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Nagaraj, K., Sakthinathan, S. & Arunachalam, S. Synthesis, CMC Determination, Antimicrobial Activity and Nucleic Acid Binding of A Surfactant Copper(II) Complex Containing Phenanthroline and Alanine Schiff-Base. J Fluoresc 24, 589–598 (2014). https://doi.org/10.1007/s10895-013-1332-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10895-013-1332-5