Folate Conjugated CdHgTe Quantum Dots with High Targeting Affinity and Sensitivity for In vivo Early Tumor Diagnosis
- 344 Downloads
CdHgTe-folate conjugates, acting as novel active-targeting fluorescence probes, were prepared by covalent conjugation of CdHgTe QDs and folic acid. Their characteristics, such as optical spectra, stability and cancer cell targeting were investigated in detail. The fluorescence wavelength of CdHgTe-folate conjugates was 790 nm and a full width at half-maximum (FWHM) of them was 50–70 nm. Their fluorescence stability could satisfy the need of long and continuous fluorescence imaging. The in vivo dynamic bio-distribution of CdHgTe-folate conjugates in S180 tumor beard mouse model was monitored by a NIR imaging system. The resultes indicated that CdHgTe-folate conjugates targeted to tumor effectively. The high fluorescence intensity together with targeting effect makes CdHgTe-folate conjugates promising candidates for imaging, monitoring and early diagnosis of cancer at molecular and cell level.
KeywordsCdHgTe Folate Near infrared imaging Cancer Targeting
The authors are grateful to Natural Science Foundation Committee of China (NSFC81000666, NSFC81071194, NSFC30970776, NSFC30700779), the Ministry of Science and Technology (2009ZX09310-004), the Ministry of Education of China and China Pharmaceutical University for their financial supports.
- 1.Fottner C, Mettler E, Goetz M, Schirrmacher E, Anlauf M, Strand D, Schirrmacher R, Klöppel G, Delaney P, Schreckenberger M, Galle PR, Neurath MF, Kiesslich R, Weber MM (2010) In vivo molecular imaging of somatostatin receptors in pancreatic islet cells and neuroendocrine tumors by miniaturized confocal laser-scanning fluorescence microscopy. Endocrinology 151(5):2179–2188PubMedCrossRefGoogle Scholar
- 23.Liu F, Deng D, Chen X, Qian Z, Achilefu S, Gu Y (2010) Folate-polyethylene glycol conjugated near-infrared fluorescence probe with high targeting affinity and sensitivity for in vivo early tumor diagnosis. Mol Imaging Biol Apr 8. [Epub ahead of print]Google Scholar