Skip to main content

Advertisement

SpringerLink
Log in

Multiple Sclerosis in an Individual with Intellectual Disability

  • Original Article
  • Published:
Journal of Developmental and Physical Disabilities Aims and scope Submit manuscript

Abstract

Multiple sclerosis (MS) is a neurological disorder that affects mostly young adults. Because of the complex mixture of neurological symptoms and cognitive-emotional changes during active phases of the disorder, MS can be confused with several psychiatric disorders. This case study of an individual with a mixed mood disorder, MS and Intellectual and Developmental Disability (IDD) illustrate the complex nature of this problem.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Adams, R. D., Victor, M., & Ropper, A. H. (1997). Principles of neurology. New York: McGraw-Hill.

    Google Scholar 

  • Asghar-Ali, A., Taber, K., Hurley, R. A., & Hayman, L. A. (2004). Pure neuropsychiatric presentation of multiple sclerosis. Journal of American Psychiatric Association, 161(2), 226–231.

    Article  Google Scholar 

  • Benedict, R. H., Priore, R., Miller, C., Munschauer, F., & Jacobs, L. (2001). Personality disorder in multiple sclerosis with cognitive impairment. Journal of Neuropsychiatry and Clinical Neuroscience, 13(1), 70–76.

    Google Scholar 

  • Brassington, J. C., & Marsh, N. V. (1998). Neuropsychological aspects of multiple sclerosis. Neuropsychological Reviews, 8, 43–77.

    Article  Google Scholar 

  • Comi, G., Filipi, M., Martinelli, V., Campi, A., Rodegher, M., & Alberoni, M. (1995). Brain MRI correlates of cognitive impairment in primary and secondary progressive multiple sclerosis. Journal of Neurological Sciences, 132, 222–227.

    Article  Google Scholar 

  • Cummings, J. L. (Ed.). (1990). Subcortical dementia. New York: Oxford University Press.

  • Denney, D. D., Lynsch, S., Parmenter, B. A., & Horne, N. (2004). Cognitive impairment in relapsing and primary progressive multiple sclerosis: Mostly a matter of speed. Journal of International Neuropsychological Society, 10(7), 948–956.

    Article  Google Scholar 

  • Diaz-Olavarreta, C., Cummings, J. L., Velasquez, J., & Garcia de la Cadena, C. (1999). Neuropsychiatric manifestations of multiple sclerosis. The Journal of Neuropsychiatry and Clinical Neurosciences, 11(2), 51–57.

    Google Scholar 

  • Dooley, J. M., & Wright, B. (1985). Adrenoleukodystrophy mimicking multiple sclerosis. Canadian Journal of Neurological Science, 12(1), 73–74.

    Google Scholar 

  • Feinstein, A., Feinstein, K., Gray, T., & O’Connor, P. (1997). Prevalence and neurobiological correlates of pathological laughing and crying in multiple sclerosis. Archives Neurology, 54(9), 1116–1121.

    Google Scholar 

  • Filley, C. M. (2003). White matter disorders. In R. B. Schiffer, & B. S. Fogel (Eds.) Neuropsychiatry: Second edition (pp. 991–1016). Baltimore: Lippincott, Williams, and Wilkins.

    Google Scholar 

  • Haase, C. G., Tinnefield, M., Maum, I., Ganze, R. E., Haupts, M., & Faustman, P. M. (2004). Cognitive but not mood dysfunction develops in multiple sclerosis during 7-year follow-up. European Journal of Neurology, 52(2), 92–95.

    Article  Google Scholar 

  • Heesen, C., Koehler, G., Gross, R., Tessmer, W., Schultz, K. H., & Gold, S. M. (2005). Altered Cytokine responses to cognitive stress in multiple sclerosis patients with fatigue. Multiple Sclerosis, 11(1), 51–57.

    Article  PubMed  Google Scholar 

  • Kesselring, J., & Klement, U. (2001). Cognitive and affective disturbances in multiple sclerosis. Journal of Neurology, 248, 180–183.

    Article  PubMed  Google Scholar 

  • Khromov, A., Segal, M., Nissinoff, J., & Fast, A. (2005). Migraines linked to interferon-beta treatment in multiple sclerosis. American Journal of Physical Medical Rehabilitation, 84(9), 644–647.

    Article  Google Scholar 

  • Kujali, P., Partin, R., & Ruutiainen, J. (1997). The progress of decline in multiple sclerosis. Brain, 120, 289–297.

    Article  Google Scholar 

  • Kumar, A. J., Kohler, W., Kruse, B., Naidu, S., Bergin, A., Edwin, D., et al. (1995). MR Findings in adult-onset adrenoleukodystrophy. American Journal of Neuroradiology, 16(6), 1127–1137.

    Google Scholar 

  • Madden, K. S., Bellinger, D., & Ackerman, K. (2003). Psychoneuroimmunology interaction between the brain and the immune system. In R. B. Schiffer, & B. S. Fogel (Eds.) Neuropsychiatry: Second edition (pp. 245–271). Baltimore: Lippincott, Williams, Wilkins.

    Google Scholar 

  • Matthews, P. M., deStefano, N., Narayana, S., Francis, G. S., Wolinsky, J. S., & Antel, J. P. (1998). Putting magnetic resonance spectroscopy studies in context: Axonal damage and disability in multiple sclerosis. Seminars in Neurology, 18, 327–336.

    PubMed  Google Scholar 

  • Mc Guinness, M. C., Powers, J., Bias, W. B., Schmeckpaper, B. J., et al. (1997). Human leukocyte antigens and cytokine expression in cerebral inflammatory demyelinative lesions of x-linked adrenoleukodystophy and multiple sclerosis. Journal of Neuroimmunology, 75(1–2), 174–182.

    Article  Google Scholar 

  • Metz L. (1998). Multiple sclerosis: Symptomatic therapies. Seminars in Neurology, 18(3), 389–395.

    Google Scholar 

  • Olek, M. J. (2005). Treatment of progressive multiple sclerosis. UpToDate Online.

  • O’Riordan, J. I. (1997). Central nervous system white matter diseases other than multiple sclerosis. Current Opinions in Neurology, 10(3), 211–214.

    Article  Google Scholar 

  • Ralph, H. B., Bakersmith, R., Simon, J. H., Priore, R., Miller, C., & Munchauser, M. (2002). Frontal cortex atrophy predicts cognitive impairment in multiple sclerosis. Journal of Neuropsychiatry and Clinical Neurosciences, 14, 44–51.

    Google Scholar 

  • Savettieri, G., Messino, D., Andreoi, V., Catlagirone, C., et al. (2004). Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis. Journal of Neurology, 251(10), 1208–1214.

    Article  PubMed  Google Scholar 

  • Rao SM. (Ed.). (1990). Neurobehavioral aspects of multiple sclerosis. New York: Oxford University Press.

  • Solaro, C., Uccelli, M., & Mancardi, G. L. (1999). A patient with multiple sclerosis and Down’s syndrome with a rare paroxysmal onset. European Journal of Neurology, 6(4), 505–507.

    Article  PubMed  Google Scholar 

  • Sorenson, T. L., & Rensohoff, R. (1998). Etiology and pathogenesis of multiple sclerosis. Seminars in Neurology, 18(3), 287–294.

    Google Scholar 

  • van Reekum, R., Stuss, D., & Ostrander, L. (2005). Apathy: Why care? Journal of Neuropsychiatry and Clinical Neuroscience, 17(1), 7–19.

    Google Scholar 

  • Weilbach, F. X., & Toyka, K. (2002). Does Down’s syndrome protect against multiple sclerosis? European Neurology, 47(1), 52–55.

    Article  PubMed  Google Scholar 

  • Weinshenker, G. (1998). The natural history of multiple sclerosis. Seiminars in Neurology, 18(3), 301–308.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC, 27599-7160, USA

    Jarrett Barnhill

Authors
  1. Jarrett Barnhill
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jarrett Barnhill.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Barnhill, J. Multiple Sclerosis in an Individual with Intellectual Disability. J Dev Phys Disabil 20, 275–282 (2008). https://doi.org/10.1007/s10882-007-9096-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10882-007-9096-y

Keywords

Search

Navigation