The impact of obesity on pulmonary deterioration in patients undergoing robotic-assisted laparoscopic prostatectomy

  • Sebastian Blecha
  • Marion Harth
  • Florian Zeman
  • Timo Seyfried
  • Matthias Lubnow
  • Maximilian Burger
  • Stefan Denzinger
  • Michael T. Pawlik
Original Research
  • 4 Downloads

Abstract

Obesity affects respiratory and hemodynamic function in anesthetized patients. The aim of this study was to evaluate the influence of the body mass index (BMI) on pulmonary changes in a permanent 45° steep Trendelenburg position (STP) during robotic-assisted laparoscopic prostatectomy (RALP). 51 patients undergoing RALP under standardized anesthesia were included. Perioperative pulmonary function and oxygenation were measured in awake patients (T0), 20 min after the induction of anesthesia (T1), after insufflation of the abdomen in supine position (T2), after 30 min in STP (T3), when controlling Santorini’s plexus in STP (T4), before awakening while supine (T5), and after 45 min in the recovery room (T6). Patient-specific and time-dependent factor on ventilation and predicted peak inspiratory pressure (PIP), driving pressure (Pdriv) and lung compliance (LC) in a linear regression model were calculated. PIP and Pdriv increased significantly after induction of capnoperitoneum (T2–4) (p < 0.0001). In univariate mixed effects models, BMI was found to be a significant predictor for PIP and Pdriv increase and LC decrease. Obese patients a BMI > 31 kg/m2 reached critical PIP values ≥ 35 cmH2O. Postoperative oxygenation represented by the PaO2/FiO2 ratio was significantly decreased compared to T0 (p < 0.0001). Obesity in combination with STP and capnoperitoneum during RALP has a profound effect on pulmonary function. Increased PIP and Pdriv and decreased LC are directly correlated with a high BMI. Changes in PIP, Pdriv and LC during RALP may be predicted in relation to patient’s BMI for consideration in the preoperative setting. Trial registration number Z-2014-0387-6. Registered on 8 July 2014.

Keywords

Lung compliance Driving pressure Obesity Peak inspiratory pressure Robotic-assisted laparoscopic prostatectomy Steep Trendelenburg position 

Abbreviations

ASA

American Society of Anesthesia

BE

Base excess

BMI

Body mass index

etCO2

End tidal CO2

FiO2

Inspiratory fraction of oxygen

LC

Lung compliance

MAP

Mean arterial blood pressure

MV

Minute ventilation

PaCO2

Partial arterial carbon dioxide fraction

PaO2

Partial arterial oxygen fraction

Pdriv

Driving pressure

PEEP

Positive end-expiratory pressure

PIP

Peak inspiratory pressure

RALP

Robotic-assisted laparoscopic prostatectomy

STP

Steep Trendelenburg position

TIVA

Total intravenous anesthesia

TOF

Train-of-four

Notes

Availability of data and material

All data generated or analyzed during this study are included in this published article and are available from the corresponding author on reasonable request.

Authors’ contributions

SB: Ethics approval, study design, data collection and analysis, drafted the manuscript and reviewed it for important intellectual content; MH: Idea for study, study design, patient recruitment, data collection and finally reviewed the manuscript for important intellectual content; FZ: Data analysis and interpretation, finally reviewed the manuscript for important intellectual content; TS: Made acquisitions, interpret data and finally reviewed the manuscript for important intellectual content; ML: Made acquisitions, interpret data and finally reviewed the manuscript for important intellectual content; MB: Made acquisitions, interpret data and finally reviewed the manuscript for important intellectual content; SD: Made acquisitions and interpret of data and finally reviewed the manuscript for important intellectual content; MP: Idea for study, study design, data collection and interpretation, patient recruitment and finally reviewed the manuscript for important intellectual content.

Compliance with ethical standards

Conflict of interest

The authors declares that they have no competing interest in relation to this paper.

Ethics approval

This study was approved by the local institutional review board of the University of Regensburg (Protocol No. 14-101-0107) and registered at the local Center for Clinical Studies (Z-2014-0387-6. Registered on 8 July 2014).

Informed consent

After detailed explanation, written informed consent was obtained from 51 patients scheduled for elective prostatectomy at the Department of Urology in Regensburg.

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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of AnesthesiologyUniversity Medical Center RegensburgRegensburgGermany
  2. 2.Department of Anesthesiology, Caritas St. Josef Medical CenterUniversity of RegensburgRegensburgGermany
  3. 3.Centre for Clinical StudiesUniversity Medical Center RegensburgRegensburgGermany
  4. 4.Department of Internal Medicine IIUniversity Medical Center RegensburgRegensburgGermany
  5. 5.Department of Urology, Caritas St. Josef Medical CenterUniversity of RegensburgRegensburgGermany

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