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RETRACTED ARTICLE: Effects of ultrasound-guided stellate-ganglion block on sleep and regional cerebral oxygen saturation in patients undergoing breast cancer surgery: a randomized, controlled, double-blinded trial

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This article was retracted on 01 June 2023

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Abstract

Numerous factors could contribute to sleep disturbances in women with breast cancer. We hypothesized that stellate ganglion block (SGB) during surgery would preserve sleep after surgery and increase intraoperative regional cerebral oxygen saturation (rSO2) on the blocked side in patients undergoing breast cancer surgery. A randomized, double-blinded, controlled trial was conducted at the First Hospital of China Medical University from January 2016 to September 2016. Ninety-six patients who underwent radical breast cancer surgery requiring general anaesthesia were randomly assigned to one of two study groups: a control group that received a saline SGB and a block group that received a 0.25% ropivacaine hydrochloride SGB. The primary outcome measure was the postoperative sleep profile, which was assessed using the bispectral index on the first postoperative night. The secondary outcome measure was the intraoperative rSO2, monitored was throughout surgery using near-infrared spectroscopy. A total of 91 female patients (mean age: 45 years; range 24–51 years) were included in the study. The duration of sleep was significantly increased by 66.3 min in the ropivacaine-SGB group compared with the saline-SGB group. No differences in rSO2 were observed on either the left or right side of the patients in either group 50 min after anaesthesia induction. We conclude that ropivacaine-SGB combined with general anaesthesia might increase the first postoperative sleep duration without influencing the intraoperative rSO2 in female patients undergoing elective breast cancer surgery.


Clinical trials.gov identifier NCT02651519

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Funding

This work was funded by the Natural Science Foundation of Liaoning Province (2014021035) to Wen-fei Tan.

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Authors and Affiliations

  1. Department of Anaesthesiology, The First Hospital of China Medical University, 155# Nanjingbei Street, Shenyang, China

    Feng Jin, Xiao-qian Li, Wen-fei Tan, Hong Ma, Bo Fang, A-yong Tian & Huang-wei Lu

Authors
  1. Feng Jin
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  2. Xiao-qian Li
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  3. Wen-fei Tan
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  4. Hong Ma
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  5. Bo Fang
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  7. Huang-wei Lu
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Corresponding author

Correspondence to Wen-fei Tan.

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Conflict of interest

The authors declare that there are no conflicts of interest arising from this study.

Ethics approval

The trial was approved by the Ethics Committee of the First Hospital of China Medical University (protocol number 2015110302, Chairman Prof. Xing-hua Gao, December 14, 2015, Trial registration:NCT02651519 Principal investigator’s name: Wen-fei Tan, Date of registration: 2016-01-05 https://clinicaltrials.gov/ct2/show/NCT02651519?term=NCT02651519&rank=1) and was registered with the Clinical Trials Registry (NCT02651519).

Informed consent

All participants provided written informed consent in accordance with the Declaration of Helsinki.

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Jin, F., Li, Xq., Tan, Wf. et al. RETRACTED ARTICLE: Effects of ultrasound-guided stellate-ganglion block on sleep and regional cerebral oxygen saturation in patients undergoing breast cancer surgery: a randomized, controlled, double-blinded trial. J Clin Monit Comput 32, 855–862 (2018). https://doi.org/10.1007/s10877-017-0074-3

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  • DOI: https://doi.org/10.1007/s10877-017-0074-3

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