Journal of Clinical Monitoring and Computing

, Volume 27, Issue 1, pp 1–34 | Cite as

Shedding light on mitochondrial function by real time monitoring of NADH fluorescence: I. Basic methodology and animal studies

Review Paper


Normal mitochondrial function in the process of metabolic energy production is a key factor in maintaining cellular activities. Many pathological conditions in animals, as well as in patients, are directly or indirectly related to dysfunction of the mitochondria. Monitoring the mitochondrial activity by measuring the autofluorescence of NADH has been the most practical approach since the 1950s. This review presents the principles and technological aspects, as well as typical results, accumulated in our laboratory since the early 1970s. We were able to apply the fiber-optic-based NADH fluorometry to many organs monitored in vivo under various pathophysiological conditions in animals. These studies were the basis for the development of clinical monitoring devices as presented in accompanying article. The encouraging experimental results in animals stimulated us to apply the same technology in patients after technological adaptations as described in the accompanying article. Our medical device was approved for clinical use by the FDA.


Cellular energy metabolism In vivo monitoring Intracellular NADH autofluorescence Multiorgan monitoring Tissue oxygen balance Brain metabolism 


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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.The Mina & Everard Goodman Faculty of Life SciencesBar-Ilan UniversityRamat GanIsrael
  2. 2.The Leslie and Susan Gonda Multidisciplinary Brain Research CenterBar-Ilan UniversityRamat GanIsrael

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