Journal of Clinical Monitoring and Computing

, Volume 22, Issue 4, pp 327–332 | Cite as

Investigation of Pulse Transit Time Characteristics During Single and Recurrent Obstructive Respiratory Events

  • Jong Yong A. Foo
  • Stephen J. Wilson
  • Gordon R. Williams
  • Margaret-Ann Harris
  • David M. Cooper


Conventional overnight polysomnography (PSG) used to determine the respiratory behaviour during sleep can be a complex and expensive procedure. Pulse transit time analysis (PTT) has shown potential to detect obstructive apnoeic and hypopnoeic events (OE) in adults. Due to abnormalities in central ventilatory control, recurring OE may occur. This study was undertaken to determine the potential of PTT to differentiate responses during upper airway obstruction in the paediatric population. This preliminary study included 11 children (10 male; aged 7.5 ± 3.8 year) recruited to investigate PTT trend during single and recurrent OE. PTT measurements were evaluated against the corresponding PSG results pre-scored by two blinded obsercvers. A total of 110 valid OE (47 single and 63 recurrent) were observed during these PSG studies. There were distinct PTT responses observed for these two types of OE with respect to those of tidal breathing (P < 0.05). For the tidal breathing events, the mean absolute standard deviation (SD) and maximal percentage (%) decrease (MAX) were 7.71 ms and 3.88% respectively. For the recurrent OE, the absolute SD, SD (%) and MAX were 52.21 ms, 8.52% and 55.08% accordingly while for the single OE, the absolute SD, SD (%) and MAX were 12.23 ms, 5.27% and 13.56% respectively. The findings herein can suggest that PTT can be a valuable clinical tool in the paediatric respiratory sleep studies.


sleep-disordered breathing paediatrics non-invasive monitoring cardiovascular photoplethysmography 


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Jong Yong A. Foo
    • 1
    • 2
  • Stephen J. Wilson
    • 3
  • Gordon R. Williams
    • 4
  • Margaret-Ann Harris
    • 4
  • David M. Cooper
    • 4
  1. 1.Division of ResearchSingapore General HospitalSingaporeSingapore
  2. 2.Biomedical Engineering Research CentreNanyang Technological UniversitySingaporeSingapore
  3. 3.School of Information Technology and Electrical EngineeringUniversity of QueenslandBrisbaneAustralia
  4. 4.Department of Respiratory and Sleep MedicineMater Misericordiae Children’s HospitalSouth BrisbaneAustralia

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