Structural Diversity of Co(II) Coordination Polymers: Treatment Activity on Hypotension During Surgery by Blocking α Receptor on Peripheral Blood Vessels


Two Co(II)-based coordination polymers (CPs) with the molecular formulae of [Co4(5-mtz)4(l-mal)2(H2O)2]n (1, 5-mtz = 5-methyltetrazole, L-mal = L-malic acid) and {[Co8(S-mal)4(bptc)(H2O)12]·0.5H4bptc·7.5H2O}n (2, S-mal = S-malic acid, H4bptc = biphenyl-3,3′,5,5′-tetracarboxylic acid) were synthesized under a hydrothermal or solvothermal surrounding. The prepared two complexes have been determined through the powder and single crystal X-ray diffraction, thermogravimetric (TG) analyses and IR spectroscopy. To prevent the hypotension during surgery after injected with anesthetic, their biological activity was estimated in this research. The CCK-8 (Cell Counting Kit-8) assay was performed to measure the viability of the HUVEC cells after compounds treatment. The relative expression of the α receptor was evaluated by real time RT-PCR (reverse transcription-polymerase chain reaction). Besides, the blood pressure was measured as well.

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Data Availability

The data used to support the findings of this study are included within the article.


  1. 1.

    M. A. Pollack, G. M. Fenati, T. W. Pennington, D. J. Olvera, A. Wolfe, M. Owens, and D. P. Davis (2020). Air Med. J. 39, 111.

    Article  Google Scholar 

  2. 2.

    M. Mojtahedzadeh, H. Taghvaye-Masoumi, A. Najafi, M. Dianatkhah, H. Sharifnia, and M. Shahrokhi (2019). Iran. J. Pharm. Res. 18, 2131.

    Google Scholar 

  3. 3.

    G. Putz and C. J. Wiedermann (2020). J. Anaesthesiol. Clin. Pharmacol. 36, 102.

    Article  Google Scholar 

  4. 4.

    M. Rancan and L. Armelao (2015). Chem Commun. 51, 12947.

    CAS  Article  Google Scholar 

  5. 5.

    J. X. Li, Z. X. Du, Q. Y. Pan, L. L. Zhang, and D. L. Liu (2020). Inorg. Chim. Acta 509, 119677.

    CAS  Article  Google Scholar 

  6. 6.

    J. X. Li, Z. X. Du, L. L. Zhang, D. L. Liu, and Q. Y. Pan (2020). Inorg. Chim. Acta 512, 119890.

    CAS  Article  Google Scholar 

  7. 7.

    J. X. Li and Z. X. Du (2020). J. Clust. Sci. 31, 507.

    CAS  Article  Google Scholar 

  8. 8.

    W. Liu, H. Li, H. Zhu, and P. Xu (2020). Materials 13, 1180.

    CAS  Article  Google Scholar 

  9. 9.

    J. X. Li, Z. X. Du, and X. Feng (2019). Z. Naturforsch. 74, 833.

    CAS  Article  Google Scholar 

  10. 10.

    C. Duan, Z. Su, Y. Cao, L. Hu, D. Fu, J. Ma, and Y. Zhang (2021). J. Clean. Prod. 283, 124635.

    CAS  Article  Google Scholar 

  11. 11.

    H. Du, C. Ma, W. Ma, and H. Wang (2018). Process Appl. Ceram. 12, 303.

    CAS  Article  Google Scholar 

  12. 12.

    N. Wang, Y. C. Feng, W. Shi, B. Zhao, P. Cheng, D. Z. Liao, and S. P. Yan (2012). CrystEngComm 14, 2769.

    CAS  Article  Google Scholar 

  13. 13.

    R. F. D’Vries, V. A. D. L. Pena-O’Shea, Á. B. Hernández, N. Snejko, E. Gutiérrez-Puebla, and M. A. Monge (2014). Cryst. Growth Des. 14, 5227.

    Article  Google Scholar 

  14. 14.

    Y. N. Ren, W. Xu, L. X. Zhou, and Y. Q. Zheng (2017). J. Solid State Chem. 251, 105.

    CAS  Article  Google Scholar 

  15. 15.

    P. F. Gao, L. L. Zheng, L. J. Liang, X. X. Yang, Y. F. Li, and C. Z. Huang (2013). J. Mater. Chem. B 1, 3202.

    CAS  Article  Google Scholar 

  16. 16.

    Y. Xu, F. Ding, D. Liu, P. P. Yang, and L. L. Zhu (2018). J. Mol. Struct. 1155, 72.

    CAS  Article  Google Scholar 

  17. 17.

    Q. Q. Xiao, G. Y. Dong, Y. H. Li, and G. H. Cui (2019). Inorg. Chem. 58, 15696.

    CAS  Article  Google Scholar 

  18. 18.

    M. Y. Li, F. Wang, and J. Zhang (2017). Inorg. Chem. Commun. 79, 37.

    Article  Google Scholar 

  19. 19.

    M. S. Zavakhina, D. G. Samsonenko, and V. P. Fedin (2019). J. Struct. Chem. 60, 279.

    CAS  Article  Google Scholar 

  20. 20.

    F. P. Dwyer, E. C. Gyarfas, W. P. Rogers, and J. H. Koch (1952). Nature 170, 190.

    CAS  Article  Google Scholar 

  21. 21.

    M. D. Hall, T. W. Failes, N. Yamamoto, and T. W. Hambley (2007). Dalt. Trans. 170, 3983.

    Article  Google Scholar 

  22. 22.

    H. López-Sandoval, M. E. Londoño-Lemos, R. Garza-Velasco, I. Poblano-Meléndez, P. Granada-Macías, I. Gracia-Mora, and N. Barba-Behrens (2008). J. Inorg. Biochem. 102, 1267.

    Article  Google Scholar 

  23. 23.

    I. Ott, A. Abraham, P. Schumacher, H. Shorafa, G. Gastl, R. Gust, and B. Kircher (2006). J. Inorg. Biochem. 100, 1903.

    CAS  Article  Google Scholar 

  24. 24.

    E. V. Alexandrov, V. A. Blatov, A. V. Kochetkov, and D. M. Proserpio (2011). CrystEngComm 13, 3947.

    CAS  Article  Google Scholar 

  25. 25.

    V. A. Blatov, A. P. Shevchenko, and D. M. Proserpio (2014). Cryst. Growth Des. 14, 3576.

    CAS  Article  Google Scholar 

  26. 26.

    K. Nakamoto, Infrared and Raman Spectra of Inorganic and Coordination Compounds (John Wiley & Sons, New York, 1986).

    Google Scholar 

  27. 27.

    J. Wang, D. Chen, B. Li, J. He, D. Duan, D. Shao, and M. Nie (2016). Sci. Rep. 6, 26126.

    CAS  Article  Google Scholar 

  28. 28.

    X. Wu, Y. Wen, X. Q. Tan, M. Liang, Y. Qin, and X. L. Gan (2020). J. Fluoresc. 30, 1365.

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Xinkai Wang.

Ethics declarations

Conflicts of interest

The authors declares that there is no conflict of interest regarding the publication of this paper.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Wang, X., Song, L. & Guo, H. Structural Diversity of Co(II) Coordination Polymers: Treatment Activity on Hypotension During Surgery by Blocking α Receptor on Peripheral Blood Vessels. J Clust Sci (2021).

Download citation


  • Coordination polymer
  • Single crystal X-ray diffraction
  • Hypotension