Two Metal–Organic Frameworks: Luminescent Detection Performance and Treatment Activity on Chronic Glomerulus Nephritis Mediated by E. coli Abundance Regulation


Two new metal–organic frameworks (MOFs) [Eu(Hpta)(C2O4)]·3H2O (1) and {[Co(pta)]·1.5H2O}n (2) were prepared via reaction of the corresponding metal salts with a bifunctional organic ligand 2-(4-pyridyl)-terephthalic acid (H2pta) under the solvothermal reaction conditions. The Eu(III)-based complex 1 is highly selective and sensitive to Cu2+ in the water solution, and nearly 93% of its fluorescent intensity could be quenched when the Cu2+ ion concentration is 10–2 mol/L. Complex 1 has a relative high quenching constant KSV of 1163 M−1,which might be highly related to its uncoordinated nitrogen sites for the binding with Cu2+ ion in aqueous solution as reflected by the X-ray photoelectron spectroscopy (XPS) analysis (from 399.6 eV to 400.2 eV). Furthermore, they were used for the chronic glomerulus nephritis treatment, the biological activity and detail mechanism was investigated. The CFU assay was implemented to determine the fecal bacterial numbers of Escherichia coli (E. coli) after treated with compound 1 or 2. Afterward, the western blot was implemented to determine the autophagic levels in the renal tubular endothelial cells.

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Data Availability

The data used to support the findings of this study are included within the article.


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The study was supported by National Natural Science Foundation of China (81774060).

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Correspondence to Xu-Dong Xu or Hong-Mei Huan.

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Wang, HR., He, HD., Tang, YY. et al. Two Metal–Organic Frameworks: Luminescent Detection Performance and Treatment Activity on Chronic Glomerulus Nephritis Mediated by E. coli Abundance Regulation. J Clust Sci (2021).

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  • Coordination polymer
  • Cu2+ ion detection
  • Chronic glomerulus nephritis