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Influence of the Phytosynthesis of Noble Metal Nanoparticles on the Cytotoxic and Genotoxic Effects of Aconitum toxicum Reichenb. Leaves Alcoholic Extract

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Abstract

Green nanoparticles are currently thoroughly researched due to the multiple advantages of phytosynthesis, on the one hand, and the potential beneficial or adverse effects, on the other. In this context, our study investigates the potential for the phytosynthesis of gold and silver nanoparticles of the ethanol and methanol extracts from leaves of Aconitum toxicum Rchb., as well as the enhancement of the antioxidant potential and the influence on the cytotoxic and genotoxic effects of the extracts through the action of the synthesized nanoparticles. The nanoparticles obtained were characterized using analytical techniques as UV–Visible spectrometry, X-ray diffraction, X-ray fluorescence, electron microscopy (SEM and STEM). The HPLC analysis of extracts revealed that the methanol extracts contained a higher aconitine level. The alcoholic extracts from leaves of A. toxicum Rchb. exerted mitodepressive effect and the phytomediated synthesis of Ag and Au nanoparticles diminished mitoinhibitory effect of the extracts, dependent on nanoparticles size and type. The mitostimulatory potential of the extracts supplemented with Ag nanoparticles was higher compared with that of the extracts with Au nanoparticles. In general, an influence of the extract composition on both the phytosynthesized nanoparticles and on the evaluated properties was observed, the ethanolic extract leading to gold nanoparticles with smaller dimension, while the silver nanoparticles had similar dimensions for both extracts studied. In the same time, the antioxidant properties of the extracts increased with the phytosynthesis process, a higher increase being observed upon the phytosynthesis of the silver nanoparticles (17% increase for the ethanolic extract and, respectively, 12% for the methanolic extract).

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Acknowledgements

NAS gratefully acknowledge the support obtained through the Project CIPCS_2017, Contract No. 1540/08.02.2018 from the Internal Competition of Scientific Research Projects, project financed from the University of Piteşti. RCF, CS, CD, LCS and IF gratefully acknowledge the support obtained through the Project BIOHORTINOV, Grant of the Romanian National Authority for Scientific Research and Innovation, CNCS/CCCDI – UEFISCDI, Complex Project PN-III-P1-1.2-PCCDI2017-0332; Contract: 6PCCDI/2018, within PNCDI III. SMA gratefully acknowledge the support obtained through the Project SusMAPWaste, SMIS 104323, Contract No. 89/09.09.2016, from the Operational Program Competitiveness 2014–2020, project cofinanced from the European Regional Development Fund.

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Author notes

  1. Nicoleta Anca Sutan, Irina Fierascu, and Radu Claudiu Fierascu had an equal contribution to the present paper and are considered main authors.

Authors and Affiliations

  1. Department of Natural Sciences, Faculty of Science, Physical Education and Informatics, University of Pitesti, 1 Targu din Vale Str., 110040, Pitesti, Arges, Romania

    Nicoleta Anca Sutan, Denisa Stefania Vilcoci, Angela Monica Neblea, Claudiu Sutan & Liliana Cristina Soare

  2. Emerging Nanotechnologies Group, National Institute for Research and Development in Chemistry and Petrochemistry – ICECHIM Bucharest, 202 Spl. Independentei, 060021, Bucharest, Romania

    Irina Fierascu & Radu Claudiu Fierascu

  3. Regional Research and Development Center for Innovative Materials, Products and Processes from Automotive Industry, University of Pitesti, 11 Doaga Str., 110440, Pitesti, Arges, Romania

    Catalin Ducu & Denis Negrea

  4. University of Agronomic Sciences and Veterinary Medicine Bucharest, 59 Marasti Blvd., 011464, Bucharest, Romania

    Sorin Marius Avramescu

Authors
  1. Nicoleta Anca Sutan
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  2. Denisa Stefania Vilcoci
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  3. Irina Fierascu
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  5. Claudiu Sutan
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Correspondence to Irina Fierascu or Radu Claudiu Fierascu.

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Sutan, N.A., Vilcoci, D.S., Fierascu, I. et al. Influence of the Phytosynthesis of Noble Metal Nanoparticles on the Cytotoxic and Genotoxic Effects of Aconitum toxicum Reichenb. Leaves Alcoholic Extract. J Clust Sci 30, 647–660 (2019). https://doi.org/10.1007/s10876-019-01524-9

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