References
Berzins SP, Godfrey DI, Miller JF, Boyd RL. A central role for thymic emigrants in peripheral T cell homeostasis. Proc Natl Acad Sci U S A. 1999;96(17):9787–91.
Montin D, Marolda A, L’icciardi F, DiCesare S, Ricotti E, Ferro F, et al. Immunophenotype anomalies predict the development of autoimmune cytopenia in 22q11.2 deletion syndrome. J Allergy Clin Immunol. 2019;This issue.
Piliero LM, Sanford AN, McDonald-McGinn DM, Zackai EH, Sullivan KE. T-cell homeostasis in humans with thymic hypoplasia due to chromosome 22q11.2 deletion syndrome. Blood. 2004;103(3):1020–5.
Cho JY, Min JY, Lee YH, McCrindle B, Hornberger LK, Yoo SJ. Diameter of the normal fetal thymus on ultrasound. Ultrasound Obstet Gynecol. 2007;29(6):634–8.
Bale PM, Sotelo-Avila C. Maldescent of the thymus: 34 necropsy and 10 surgical cases, including 7 thymuses medial to the mandible. Pediatr Pathol. 1993;13(2):181–90.
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The authors gratefully acknowledge the patients.
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KES is supported through the Wallace Chair of Pediatrics.
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KES and DMM formulated the study. YD performed statistical analyses. ES assembled and analyzed thymic size assessments. TBC performed data extraction of T cell counts phenotypic variables. BC, JM, and EO performed thymic size analysis.
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Dou, Y., Schindewolf, E., Crowley, T.B. et al. The Association of Fetal Thymus Size with Subsequent T Cell Counts in 22q11.2 Deletion Syndrome. J Clin Immunol 40, 783–785 (2020). https://doi.org/10.1007/s10875-020-00807-5
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DOI: https://doi.org/10.1007/s10875-020-00807-5