Unusual Severe Seborrheic Dermatitis in Two Siblings with Autosomal Recessive Chronic Granulomatous Disease

A Correction to this article was published on 02 November 2019

This article has been updated

This is a preview of subscription content, access via your institution.

Fig. 1

Change history

  • 02 November 2019

    The original version of this article contained an error in Fig. 1. The incomplete heredogram mistakenly appeared in panel <Emphasis Type="Bold">d</Emphasis>.


  1. 1.

    Clark GW, Pope SM, Jaboori KA. Diagnosis and treatment of seborrheic dermatitis. Am Fam Physician. 2015;91:185–90.

    PubMed  Google Scholar 

  2. 2.

    Berron-Ruiz L, Morin-Contreras A, Cano-Garcia V, Yamazaki-Nakashimada MA, Gomez-Tello H, et al. Detection of inheritance pattern in thirty-three Mexican males with chronic granulomatous disease through 123 dihydrorhodamine assay. Allergol Immunopathol (Madr). 2014;42:580–5.

    CAS  Article  Google Scholar 

  3. 3.

    Luis-Montoya P, Saez-de Ocariz Mdel M, Vega-Memije ME. Chronic granulomatous disease: two members of a single family with different dermatologic manifestations. Skinmed. 2005;4:320–2.

    Article  Google Scholar 

  4. 4.

    Vazquez N, Lehrnbecher T, Chen R, Christensen BL, Gallin JI, et al. Mutational analysis of patients with p47-phox-deficient chronic granulomatous disease: the significance of recombination events between the p47-phox gene (NCF1) and its highly homologous pseudogenes. Exp Hematol. 2001;29:234–43.

    CAS  Article  Google Scholar 

  5. 5.

    de Oliveira-Junior EB, Zurro NB, Prando C, Cabral-Marques O, Pereira PV, Schimke LF, Klaver S, Buzolin M, Blancas-Galicia L, Santos-Argumedo L, Pietropaolo-Cienfuegos DR, Espinosa-Rosales F, King A, Sorensen R, Porras O, Roxo-Junior P, Forte WC, Orellana JC, Lozano A, GalicchioM, Regairaz L, Grumach AS, Costa-Carvalho BT, Bustamante J, Bezrodnik L, Oleastro M, Danielian S, Condino-Neto. Clinical and genotypic spectrum of chronic granulomatous disease in 71 Latin American patients: first report from the LASID registry. A Pediatr Blood Cancer. 2015;62:2101–7.

  6. 6.

    Kamamoto CSL, Nishikaku AS, Gompertz OF, Melo AS, Hassun KM, et al. Cutaneous fungal microbiome: Malassezia yeasts in seborrheic dermatitis scalp in a randomized, comparative and therapeutic trial. Dermatoendocrinol. 2017;9:e1361573.

    CAS  Article  Google Scholar 

  7. 7.

    Park JH, Park YJ, Kim SK, Kwon JE, Kang HY, Lee ES, et al. Histopathological differential diagnosis of psoriasis and seborrheic dermatitis of the scalp. Ann Dermatol. 2016;28:427–32.

    Article  Google Scholar 

Download references


We thank our patient and his family for their participation in this study. We thank Instituto PENSI for administrative support.


This work was supported by CAPES to NBZ; The Jeffrey Modell Foundation to ACN; and PENSI Institute and Ministério da Saúde do Brasil (PRONAS/PDC 2015, 25000.077928/2015-6) to ACN.

Author information



Corresponding author

Correspondence to Antonio Condino-Neto.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethics Committee

This study was approved by the Ethics and Research Committee for Humans at the Institute of Biomedical Sciences, University of São Paulo, in accordance with the Declaration of Helsinki. Patients or parents provided written informed consent.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Zurro, N.B., de Oliveira Junior, E.B., França, T.T. et al. Unusual Severe Seborrheic Dermatitis in Two Siblings with Autosomal Recessive Chronic Granulomatous Disease. J Clin Immunol 39, 836–838 (2019). https://doi.org/10.1007/s10875-019-00681-w

Download citation