References
Kuhne T. Diagnosis and management of immune thrombocytopenia in childhood. Hamostaseologie. 2017;37(1):36–44.
Seidel MG. Autoimmune and other cytopenias in primary immunodeficiencies: pathomechanisms, novel differential diagnoses, and treatment. Blood. 2014;124(15):2337–44.
Ballow M. The IgG molecule as a biological immune response modifier: mechanisms of action of intravenous immune serum globulin in autoimmune and inflammatory disorders. J Allergy Clin Immunol. 2011;127(2):315–23 quiz 24-5.
Iuliano F, Iuliano E, Luci M, Perricelli A, Pomillo A, Abruzzese E. Subcutaneous immunoglobulin (SCIG) in responders to intravenous therapy with chronic immune thrombocytopenia (ITP). Blood. 2014;124(21):5012.
Pedini V, Savore I, Danieli MG. Facilitated subcutaneous immunoglobulin (fSCIg) in autoimmune cytopenias associated with common variable immunodeficiency. Isr Med Assoc J. 2017;19(7):420–3.
Scheuerlein P, Pietsch L, Camacho-Ordonez N, Reiser V, Patel S, Burns SO, et al. Is it safe to switch from intravenous immunoglobulin to subcutaneous immunoglobulin in patients with common variable immunodeficiency and autoimmune thrombocytopenia? Front Immunol. 2018;9:1656.
Chapdelaine H, Decaluwe H, Levasseur MC, De Deist F, Haddad E. Experience with subcutaneous immunoglobulin therapy in two pediatric cases of immune thrombocytopenia purpura. Allergy, Asthma Clin Immunol. 2012;8(Suppl 1):A23.
Cuker A, Neunert CE. How I treat refractory immune thrombocytopenia. Blood. 2016;128(12):1547–54.
DiMaggio D, Anderson A, Bussel JB. Cytomegalovirus can make immune thrombocytopenic purpura refractory. Br J Haematol. 2009;146(1):104–12.
Acknowledgements
The authors thank the patient and her family for the approval to publish her clinical history and laboratory data. MGS is in part funded by the Styrian Children’s Cancer foundation (Steirische Kinderkrebshilfe).
Author information
Authors and Affiliations
Contributions
AK and MGS designed the study. AK, DK, HL, MB, and MGS cared for the patient and collected data. AK and DK analyzed the data. MM gave relevant advice in patient care and the discussion of the data. DK drafted the manuscript and the figures.
Corresponding authors
Ethics declarations
Ethics Statement
Written informed consent was obtained from the participant’s next of kin for the publication of this patient report, which was conducted according to the Declaration of Helsinki.
Conflict of Interest
The authors declared that they have no conflict of interest.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Karastaneva, A., Klobassa, D.S., Minkov, M. et al. Successful Treatment with SCIG of a Child with Refractory Chronic ITP. J Clin Immunol 39, 19–22 (2019). https://doi.org/10.1007/s10875-018-0583-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10875-018-0583-y