Spondylodiscitis in a Boy with X-linked Agammaglobulinemia: an Unusual Occurrence
To the editor,
Children with X-linked agammaglobulinemia (XLA) have a profound defect in B-lymphocyte development due to a mutation in BTK gene located on X chromosome. This results in severe hypogammaglobulinemia and an absence of circulating B cells. These children also have small to absent tonsils, and no palpable lymph nodes despite recurrent infections . Infections include sinusitis, otitis media, pneumonia, or, less often, sepsis or meningitis. Peripheral arthritis is a well-described manifestation of XLA . Mycoplasma is an important etiological agent causing infective arthritis in children with XLA . Vertebral infections have seldom been described in XLA. We report a young boy who presented with fever, stiff-back and an unusual gait. A detailed history, clinical examination and investigations revealed a totally unexpected diagnosis of X-linked agammaglobulinemia with an unusual manifestation of spondylodiscitis.
A two year-old boy presented with fever up to 103 °F for a...
KeywordsJuvenile Idiopathic Arthritis Chronic Granulomatous Disease Pyoderma Index Child Vertebral Osteomyelitis
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Written informed consent was taken from parents of child.
Study approved by Departmental Review Board.
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