Advertisement

Journal of Clinical Immunology

, Volume 34, Issue 1, pp 39–41 | Cite as

Psychrobacter immobilis Septicemia in a Boy with X-linked Chronic Granulomatous Disease and Fulminant Hepatic Failure

  • Panida Sriaroon
  • Araceli Elizalde
  • Elena E. Perez
  • Jennifer W. Leiding
  • Grace M. Aldrovandi
  • John W. Sleasman
Astute Clinician Report

Abstract

A 16-year old boy with chronic granulomatous disease (CGD) developed Psychrobacter immobilis septicemia during a course of fulminant hepatic failure. The patient died despite aggressive management with antimicrobials and corticosteroids. While Psychrobacter immobilis rarely affects humans, it should be considered an organism that can cause sepsis in patients with CGD.

Keywords

Chronic granulomatous disease septicemia Psychrobacter immobilis hepatic failure 

Notes

Acknowledgments

We thank Dr. Jane Carver for assistance with preparation of the manuscript and Dr. Hector Monforte for the pathology diagnostic support and photomicrographs.

References

  1. 1.
    Holland SM. Chronic granulomatous disease. Clin Rev Allergy Immunol. 2010;38(1):3–10. PubMed PMID: 19504359.PubMedCrossRefGoogle Scholar
  2. 2.
    van den Berg JM, van Koppen E, Ahlin A, Belohradsky BH, Bernatowska E, Corbeel L, et al. Chronic granulomatous disease: the European experience. PLoS ONE. 2009;4(4):e5234. PubMed PMID: 19381301. Pubmed Central PMCID: PMC2668749.PubMedCentralPubMedCrossRefGoogle Scholar
  3. 3.
    Martire B, Rondelli R, Soresina A, Pignata C, Broccoletti T, Finocchi A, et al. Clinical features, long-term follow-up and outcome of a large cohort of patients with chronic granulomatous disease: an Italian multicenter study. Clin Immunol (Orlando, Fla). 2008;126(2):155–64. PubMed PMID: 18037347.CrossRefGoogle Scholar
  4. 4.
    Winkelstein JA, Marino MC, Johnston Jr RB, Boyle J, Curnutte J, Gallin JI, et al. Chronic granulomatous disease. Report on a national registry of 368 patients. Medicine. 2000;79(3):155–69. PubMed PMID: 10844935.PubMedCrossRefGoogle Scholar
  5. 5.
    Soler-Palacin P, Margareto C, Llobet P, Asensio O, Hernandez M, Caragol I, et al. Chronic granulomatous disease in pediatric patients: 25 years of experience. Allergol Immunopathol. 2007;35(3):83–9. PubMed PMID: 17594870.CrossRefGoogle Scholar
  6. 6.
    Lozano F, Florez C, Recio FJ, Gamboa F, Gomez-Mateas JM, Martin E. Fatal Psychrobacter immobilis infection in a patient with AIDS. AIDS (London, England). 1994;8(8):1189–90. PubMed PMID: 7986423.CrossRefGoogle Scholar
  7. 7.
    Bowman JP, Cavanagh J, Austin JJ, Sanderson K. Novel Psychrobacter species from Antarctic ornithogenic soils. Int J Syst Bacteriol. 1996;46(4):841–8. PubMed PMID: 8863407.PubMedCrossRefGoogle Scholar
  8. 8.
    Lloyd-Puryear M, Wallace D, Baldwin T, Hollis DG. Meningitis caused by Psychrobacter immobilis in an infant. J Clin Microbiol. 1991;29(9):2041–2. PubMed PMID: 1774332. Pubmed Central PMCID: PMC270256.PubMedCentralPubMedGoogle Scholar
  9. 9.
    Gini GA. Ocular infection caused by Psychrobacter immobilis acquired in the hospital. J Clin Microbiol. 1990;28(2):400–1. PubMed PMID: 2312690. Pubmed Central PMCID: PMC269623.PubMedCentralPubMedGoogle Scholar
  10. 10.
    Leung WK, Chow VC, Chan MC, Ling JM, Sung JJ. Psychrobacter bacteraemia in a cirrhotic patient after the consumption of raw geoduck clam. J Infect. 2006;52(6):e169–71. PubMed PMID: 16253331.PubMedCrossRefGoogle Scholar
  11. 11.
    Freeman AF, Marciano BE, Anderson VL, Uzel G, Costas C, Holland SM. Corticosteroids in the treatment of severe nocardia pneumonia in chronic granulomatous disease. Pediatr Infect Dis J. 2011;30(9):806–8. PubMed PMID: 21412179. Pubmed Central PMCID: 3151540.PubMedCentralPubMedCrossRefGoogle Scholar
  12. 12.
    Leiding JW, Freeman AF, Marciano BE, Anderson VL, Uzel G, Malech HL, et al. Corticosteroid therapy for liver abscess in chronic granulomatous disease. Clin Infect Dis Off Publ Infect Dis Soc Am. 2012;54(5):694–700. PubMed PMID: 22157170. Pubmed Central PMCID: PMC3275758.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Panida Sriaroon
    • 1
  • Araceli Elizalde
    • 2
  • Elena E. Perez
    • 3
  • Jennifer W. Leiding
    • 1
  • Grace M. Aldrovandi
    • 4
  • John W. Sleasman
    • 5
  1. 1.Division of Allergy, Immunology, and RheumatologyUniversity of South Florida Morsani College of Medicine/All Children’s HospitalSt. PetersburgUSA
  2. 2.Allergy, Asthma and Immunology Associates of South TexasSan AntonioUSA
  3. 3.University of Miami Miller School of MedicineMiamiUSA
  4. 4.Children’s Hospital of Los Angeles, University of Southern CaliforniaLos AngelesUSA
  5. 5.Pediatric Allergy and ImmunologyDuke University School of MedicineDurhamUSA

Personalised recommendations