Journal of Clinical Immunology

, Volume 33, Issue 6, pp 1057–1061 | Cite as

Recurrent Burkholderia gladioli Suppurative Lymphadenitis associated with Neutralizing Anti-IL-12p70 Autoantibodies

  • Bich-Thuy T. Sim
  • Sarah K. Browne
  • Marguerite Vigliani
  • Dalila Zachary
  • Lindsey Rosen
  • Steven M. Holland
  • Steven M. Opal
Astute Clinician Report


Burkholderia gladioli is a rare human pathogen, and pulmonary infections occur almost exclusively in cystic fibrosis, chronic granulomatous disease and lung transplant patients [1, 2, 3]. A single case of disseminated disease was described in a woman with anti-interferon gamma (IFNγ) autoantibodies [4]. Other opportunistic infections are common with defects in the IFNγ/Interleukin-12 (IL-12) pathway [5]. While high-titer neutralizing anti-IL-12 autoantibodies can occur with thymoma, their association with infections has not been clearly established [6, 7, 8]. We report a case of severe B. gladioli infection associated with autoantibodies to IL-12p70 in a Southeast Asian woman with recurring B. gladioli suppurative lymphadenitis.

Case Report

A 45-year-old Cambodian woman presented with 2 months of progressive left-sided cervical lymphadenitis and tonsillitis. Approximately 2 years earlier she had similar findings on the right side of her neck when excisional lymph node...


Thymoma Chronic Granulomatous Disease Aztreonam Control Plasma Melioidosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We wish to thank John Palardy, Nicholas Parejo and Drs. Tom Dellatorre, John Tarro, and Linda Hanley from Memorial Hospital of Rhode Island, Pawtucket, RI, for their expert assistance. We would also like to thank Drs. Alan T. Remaley and Verena Gounden and Ms. Marie Conrad of the National Institutes of Health, Bethesda, MD, for their assistance with the serum protein electrophoresis and immunofixation procedures.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Bich-Thuy T. Sim
    • 1
    • 2
    • 3
    • 6
  • Sarah K. Browne
    • 4
  • Marguerite Vigliani
    • 5
  • Dalila Zachary
    • 1
  • Lindsey Rosen
    • 4
  • Steven M. Holland
    • 4
  • Steven M. Opal
    • 1
  1. 1.The Infectious Diseases DivisionAlpert Medical School of Brown UniversityProvidenceUSA
  2. 2.Beth Israel Deaconess Medical CenterBostonUSA
  3. 3.Harvard Medical SchoolBostonUSA
  4. 4.Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA
  5. 5.Dept of Obstetrics and GynecologyAlpert Medical School of Brown UniversityProvidenceUSA
  6. 6.Ho Chi Minh CityViet Nam

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