Journal of Clinical Immunology

, Volume 32, Issue 1, pp 36–38 | Cite as

Expert Commentary: Practical Issues in Newborn Screening for Severe Combined Immune Deficiency (SCID)

  • Jennifer M. Puck
  • Jack Routes
  • Alexandra H. Filipovich
  • Kate Sullivan

Kate Sullivan: We asked experts in the field to comment on some of the more pressing questions in the burgeoning field of newborn screening for severe combined immune deficiency (SCID). Their valuable perspectives are provided to guide the establishment of policies as additional states consider and implement newborn screening for SCID. Jennifer Puck has been a strong advocate for newborn screening and originated the concept of T cell receptor excision circle (TREC) screening using dried blood spots; the TREC assay has been performed on all newborns in California since August 2010, and Dr. Puck is the immunology consultant for the California Genetic Disease Lab; she has instituted a centralized follow-up model, with the screening program obtaining and sending follow-up tests throughout the state to a single immunology lab. Dr. Puck and her Southern California colleague, Dr. Joseph Church, interpret all flow cytometric results from a designated laboratory with a standardized analytic...


SCID newborn screen bone marrow transplant T cell 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Jennifer M. Puck
    • 1
  • Jack Routes
    • 2
  • Alexandra H. Filipovich
    • 3
  • Kate Sullivan
    • 4
  1. 1.Department of PediatricsUniversity of California San Francisco and UCSF Benioff Children’s HospitalSan FranciscoUSA
  2. 2.Department of Pediatrics, Medical College of WisconsinChildren’s Hospital of WisconsinWauwatosaUSA
  3. 3.Department of PediatricsCincinnati Children’s Hospital Medical CenterCincinnatiUSA
  4. 4.Division of Allergy and ImmunologyThe Children’s Hospital of PhiladelphiaPhiladelphiaUSA

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