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Journal of Clinical Immunology

, Volume 30, Issue 3, pp 358–363 | Cite as

Navigating Barriers: The Challenge of Directed Secretion at the Natural Killer Cell Lytic Immunological Synapse

  • Keri B. Sanborn
  • Jordan S. Orange
Article

Abstract

Introduction

Natural killer (NK) cells have an inherent ability to recognize and destroy a wide array of cells rendered abnormal by stress or disease. NK cells can kill a targeted cell by forming a tight interface—the lytic immunological synapse. This represents a dynamic molecular arrangement that over time progresses through a series of steps to ultimately deliver the contents of specialized organelles known as lytic granules.

Discussion

In order to mediate cytotoxicity, the NK cell faces the challenge of mobilizing the lytic granules, polarizing them to the targeted cell, facilitating their approximation to the NK cell membrane, and releasing their contents.

Conclusion

This review is focused upon the final steps in accessing function through the lytic immunological synapse.

Keywords

NK cell cytotoxicity myosin IIA immune synapse 

Notes

Acknowledgments

This work was supported by National Institutes of Health grant R01-AI067946 (to J.S.O.). K.B.S. was supported by National Institutes of Health training grant T32-GM07229.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Immunology Graduate GroupUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.Children’s Hospital Research Institute, Children’s Hospital of PhiladelphiaPhiladelphiaUSA
  3. 3.Abramson Research Center 1014H, Division of ImmunologyChildren’s Hospital of PhiladelphiaPhiladelphiaUSA

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