CD72 Polymorphism Associated with Child-Onset of Idiopathic Thrombocytopenic Purpura in Chinese Patients
- 127 Downloads
Idiopathic thrombocytopenic purpura (ITP) is a disease putatively relating to abnormal immune function and auto-antiplatelet immunoglobulin. We examined whether polymorphism of CD72, an inhibitory receptor of B cells, affect the susceptibility to ITP, or associated with the clinical characteristics of ITP. A case-control study was carried out in 206 Chinese ITP patients and 169 healthy controls. The detection of variable number of tandem repeats in CD72 intron 8 was performed by polymerase chain reaction and subsequent analysis with polyacrylamide gel electrophoresis. We did not find direct association between CD72 genotypes and susceptibility to ITP. The haplotype that contained one repeat of 13 nucleotides in intron 8 (designated as *1, and haplotype containing two repeat of 13 nucleotides in intron 8 is designated as *2) was significantly associated with early first onset age (≤14) in ITP patients (P = 0.03). ITP patients with CD72*1\*1 and *1\*2 genotype had a 3.09-fold [95% confidence interval (CI), 1.32~7.25] and 1.98-fold (95%CI, 0.92~4.25) increased risk of appearing ITP manifestation at their childhood respectively. The haplotype CD72*1 is apparently a risk allele, whereas CD72*2 a protective allele for child-onset of ITP disease.
KeywordsCD72 polymorphism idiopathic thrombocytopenic purpura
This project was supported in part by grants of National Natural Science Foundation of China (30670900). Ministry of Education of China (20060023031), Ministry of Personnel of China (2006), and Tianjin Key Project for Basic Research (06YFJZJC01800). The authors would like to thank Prof. Man-Chiu Poon (University of Calgary, Canada) for critical review the manuscript.
- 10.Kalwak K, Gorczyńska E, Wójcik D, Toporski J, Turkiewicz D, Slociak M, et al. Late-onset idiopathic thrombocytopenic purpura correlates with rapid B-cell recovery after allogeneic T-cell-depleted peripheral blood progenitor cell transplantation in children. Transplant Proc 2002;34(8):3374–7.PubMedCrossRefGoogle Scholar
- 19.Rock KL, Benacerraf B, Abbas AK. Antigen presentation by hapten-specific B lymphocytes. Role of serface immunoglobulin receptors. J Exp Med 1984;160:1002.Google Scholar
- 30.Wang T, Zhao H, Ren H, Guo J, Xu M, Yang R, et al. Type 1 and type 2 T cells profile in chronic idiopathic thrombocytopenic purpura. Heamatologica 2005;90:914–23.Google Scholar