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Aberrant Expression of Soluble Co-stimulatory Molecules and Adhesion Molecules in Type 2 Diabetic Patients with Nephropathy

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Abstract

Co-stimulatory molecules together with leukocyte adhesion molecules are important for T lymphocyte and leukocyte-mediated inflammatory responses. We investigated the soluble costimulatory molecules CD80, CD86, CD28, and CTLA-4 and soluble adhesion molecules in plasma of 94 type 2 diabetic patients with or without nephropathy (DN and NDN) and 20 healthy controls. Plasma concentration of sCTLA-4 was significantly lower, whereas sCD28 was significantly higher in DN patients than that in control subjects (all P < 0.05). sCD28 and sCD80 were found to be positively correlated with fasting urine albumin: creatinine ratio in DN patients but not in NDN patients. Elevated soluble adhesion molecule vascular cell adhesion molecule-1 and P-selectin could be related with the disease severity of DN (all P < 0.05). Therefore, the aberrant expression of soluble co-stimulatory molecules and adhesion molecules can be related to the activation of T cells and leukocytes in the progression of inflammation in diabetic nephropathy.

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Acknowledgements

The study was supported by a Direct Grant for Research, The Chinese University of Hong Kong.

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Authors and Affiliations

  1. Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong

    C. K. Wong, Amy W. Y. Ho & Christopher W. K. Lam

  2. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong

    Peter C. Y. Tong, C. Y. Yeung, Juliana C. N. Chan & Alice P. S. Kong

  3. Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology Foundation, Taipa, Macau

    Christopher W. K. Lam

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  1. C. K. Wong
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  2. Amy W. Y. Ho
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Correspondence to Christopher W. K. Lam.

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Wong, C.K., Ho, A.W.Y., Tong, P.C.Y. et al. Aberrant Expression of Soluble Co-stimulatory Molecules and Adhesion Molecules in Type 2 Diabetic Patients with Nephropathy. J Clin Immunol 28, 36–43 (2008). https://doi.org/10.1007/s10875-007-9137-4

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  • DOI: https://doi.org/10.1007/s10875-007-9137-4

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