Chronic Granulomatous Disease with Unusual Clinical Manifestation, Outcome, and Pattern of Inheritance in an Iranian Family
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Abstract CGD is a rare phagocytic disorder manifesting as recurrent, severe bacterial and fungal infections. We describe an Iranian family with eight children, of whom six, five males and one female were diagnosed with CGD resulting in diffuse pulmonary sterile granulomatous lesions. Three died despite multiple courses of antibiotic and antituberculosis medications while three are alive, to date they are asymptomatic but with imaging and pathologic findings of pulmonary granulomatosis, treated with steroids. The parents are healthy. Our report describes the clinical manifestations and outcome in this family. The inheritance pattern suggests an autosomal recessive pattern with high penetrance.
KEY WORDS:CGD familial pattern of inheritance outcome
We thank Dr Kevin R. Elwood for critical review of the manuscript.
- 10.Mansouri D, Adimi P, Mirsaedi M, Mansouri N, Tabarsi P, Amiri M, Jamaati HR, Motavasseli M, Baghaii N, Cheraghvandi A, Rouhi R, Roozbahany NA, Zahirifard S, Mohammadi F, Masjedi MR, Velayati AA, Casanova JL, Speert DP, Elwood RK, Schellenberg R,Turvey SE: Primary immune deficiencies presenting in adults: Seven years of experience from Iran. J Clin Immunol 25:385–391, 2005PubMedCrossRefGoogle Scholar