Journal of Chemical Crystallography

, Volume 46, Issue 4, pp 181–187 | Cite as

The Crystal Structures of Three Rhodanine-3-Carboxylic Acids

  • Waldemar Tejchman
  • Agnieszka Skórska-Stania
  • Ewa Żesławska
Original Paper


The rhodanine derivatives show various pharmacological activities. Rhodanine-3-carboxylic acids can be used as the substrates in various synthesis of compounds containing rhodanine-3-carboxyalkyl moiety. In this paper new crystal structures of rhodanine-3-acetic acid and its two homologues, i.e. rhodanine-3-propionic acid and rhodanine-3-butyric acid, are reported. The relationship between the length of the alkyl chain and the geometry of these molecules was studied. The crystal network is dominated by strong hydrogen bonds O–H···O formed by the carboxyl groups. Additionally, weak C–H···O and C–H···S contacts are observed.

Graphical Abstract

To study the difference in intermolecular interactions of rhodanine-3-carboxylic acid, three crystal structures were determined by X-ray diffraction method. The crystal network in all studied structures is built of homosynthons and stabilized by weak C–H···O and C–H···S contacts.


Rhodanine-3-acetic acid N-(carboxyalkyl)rhodanine X-ray crystal structure Intermolecular interactions Thiazolidine ring 


Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Waldemar Tejchman
    • 1
  • Agnieszka Skórska-Stania
    • 2
  • Ewa Żesławska
    • 1
  1. 1.Department of Chemistry, Institute of BiologyPedagogical UniversityKrakówPoland
  2. 2.Faculty of ChemistryJagiellonian UniversityKrakówPoland

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