Abstract
Here, we compare structures determined by X-ray diffraction and subsequent Hirshfeld surface analysis to identify and understand the non-covalent interactions within the lattices of chromone, 6-methylchromone, 6-methoxychromone, 6-fluorochromone, and 6-chlorochromone with reported 6-bromochromone. In chromone, H-bonds and CH–л interactions predominate. H-bonds and aryl-stacking interactions are distinct in 6-methylchromone and 6-methoxychromone. The 6-fluorochromone, showed two types of H-bonds with O···H bonds having a greater contribution than F···H. In contrast, 6-chlorochromone and 6-bromochromone, the halogen contributes the larger percentage of stabilizing H-bonding with Cl···H and Br···H predominating over the O···H bonds. Compound 1 crystallizes in the monoclinic space group P21 /n with a = 8.1546(8) Å, b = 7.8364(7) Å, c = 11.1424(11) Å, β = 108.506(2)° and Z = 4. Compound 2 crystallizes in the triclinic space group P-1 with a = 7.0461(3) Å, b = 10.2108(5) Å, c = 10.7083(5) Å, α = 89.884(2)°, β = 77.679(2)°, γ = 87.367(2)° and Z = 4. Compound 3 crystallizes in the monoclinic space group P21/n with a = 8.1923(4) Å, b = 7.0431(3) Å, c = 15.3943(8) Å, β = 92.819(2)° and Z = 4. Compound 4 crystallizes in the triclinic space group P1 with a = 3.7059(2) Å, b = 6.1265(4) Å, c = 7.6161(5) Å, α = 84.085(3)°, β = 87.070(3)°, γ = 83.390(3)° and Z = 1. Compound 5 crystallizes in the monoclinic space group P2 1 with a = 3.8220(2) Å, b = 5.6985(2) Å, c = 16.9107(7) Å, β = 95.8256(18)° and Z = 2.
Graphical Abstract
The effect of substituents at the 6-position on chromone on their crystal structures using Hirshfeld surface and fingerprint analysis.
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This research was supported by the National Science Foundation CHE-1305136.
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Salpage, S.R., Smith, M.D. & Shimizu, L.S. Crystal Structures and Hirshfeld Surface Analyses of 6-Substituted Chromones. J Chem Crystallogr 46, 170–180 (2016). https://doi.org/10.1007/s10870-016-0642-2
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DOI: https://doi.org/10.1007/s10870-016-0642-2