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Journal of Chemical Crystallography

, Volume 40, Issue 4, pp 387–390 | Cite as

Synthesis and Crystal Structure of (S)-2-((S)-2-(N-Ts-Amino)-3-methylbutanoyl)-3-(1H-indol-3-yl)-6-phenyl-3,4-dihydro-1,2,4-triazin-5(2H)-one

  • Ilya N. Egorov
  • Vladimir L. Rusinov
  • Pavel A. Slepukhin
  • Oleg N. Chupakhin
Communication

Abstract

The diastereoselective synthesis, NMR and X-ray structure of (S)-2-((S)-2-(N-Ts-amino)-3-methylbutanoyl)-3-(1H-indol-3-yl)-6-phenyl-3,4-dihydro-1,2,4-triazin-5(2H)-one—a potential antivirus agent are reported. The compound crystallizes in the triclinic space group P1 with unit cell parameters: a = 5.9259(6) Å, b = 9.6370(12) Å, c = 12.9541(9) Å, α = 109.210(9)°, β = 90.804(7)°, γ = 105.074(10)° and Z = 1.

Graphical Abstract

The diastereoselective synthesis, NMR and X-ray structure of (S)-2-((S)-2-(N-Ts-Amino)-3-methylbutanoyl)-3-(1H-indol-3-yl)-6-phenyl-3,4-dihydro-1,2,4-triazin-5(2H)-one—a potential antivirus agent are reported.

Keywords

Antivirus agent Crystal structure 1,2,4-Triazinone Asymmetric synthesis Amino acid 

Notes

Acknowledgments

This work was supported by the program of the Russian Federation President for government support of young scientists, MK-1157.2009.3.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ilya N. Egorov
    • 1
  • Vladimir L. Rusinov
    • 1
  • Pavel A. Slepukhin
    • 2
  • Oleg N. Chupakhin
    • 1
    • 2
  1. 1.Department of Organic ChemistryUrals State Technical UniversityEkaterinburgRussian Federation
  2. 2.Institute of Organic SynthesisUral Branch of the Russian Academy of SciencesEkaterinburgRussian Federation

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