Synthesis and Structures of Two Functionalized Isobenzofurans: (3aR,7aR,4S,5S)-1,3,3a,4,5,7a-Hexahydro-5-methyl-3-oxoisobenzofuran-4-carboxylic acid and (3aα,4β,7β,7aα)-4-[(Acetyloxy)methyl]-3a,4,7,7a-tetrahydro-7-methyl-1,3-isobenzofurandione
- 607 Downloads
The title compounds, C10H12O4 and C12H14O5, were prepared as part of an ongoing study to explore the practical aspects of solventless reaction methods. As confirmed by the crystal structures, treatment of maleic anhydride with (2E,4E)-hexa-2,4-dien-1-ol or its acetate counterpart resulted in cis bicyclo [4.3.0] molecular frameworks. The racemic product derived from the dienol synthon crystallized in chiral space group P212121 via a pasteurian resolution process with molecules organized by carboxyl⋯carboxyl and C–H⋯O contacts. The acetate derivative crystallizes in space group Cc.
KeywordsCrystal structure Hydrogen bonds Isobenzofuran Bicyclo Green chemistry Diels–Alder
The authors acknowledge National Science Foundation (0722547 and DUE-9952602) for support of this crystallographic investigation. High field NMR spectra were provided by NMR Analysis & Consulting of Decatur, IL.
- 1.McKenzie LM, Huffman LM, Hutchison JE, Rogers CE, Goodwin TE, Spessard GO (2009) J Chem Ed 86:488Google Scholar
- 4.Bruker (2008) APEX2 (Version 2008.6-1), SADABS (Version 2008/1), SAINT (Version 7.56), and XPREP (Version 2008/2). Bruker AXS Inc., Madison, Wisconsin, USAGoogle Scholar
- 6.Sheldrick GM (2008) Acta Cryst C64:112Google Scholar