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Modeling of a single nanoparticle interaction with the human blood plasma proteins

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Abstract

When nanoparticles are introduced into a physiological environment, proteins and lipids immediately cover their surface, forming a protein “corona”. It is well recognized that the corona structure influences the biological response of the body. Two deterministic models for corona formation of the human blood serum proteins around a single nanoparticle are presented and studied numerically in this paper. One of them is based on a coupled system of PDEs and involves diffusion of proteins toward the nanoparticle surface. The other one is described by ODEs and is a limit version of the first model as the protein diffusivity tends to infinity. The protein diffusivity influence on the temporal corona structure is studied in detail. Results are presented using figures and discussion.

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Acknowledgements

We are grateful to Drs. M. Galagudza and A. Myasnikov who drew our attention to the nanoparticle–protein corona formation problem and anonymous reviewers whose valuable suggestions helped to improve this paper.

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  1. Faculty of Mathematics and Informatics, Vilnius University, Naugarduko 24, LT-03225, Vilnius, Lithuania

    Vladas Skakauskas & Pranas Katauskis

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  1. Vladas Skakauskas
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  2. Pranas Katauskis
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Correspondence to Vladas Skakauskas.

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Skakauskas, V., Katauskis, P. Modeling of a single nanoparticle interaction with the human blood plasma proteins. J Biol Phys 44, 605–617 (2018). https://doi.org/10.1007/s10867-018-9509-4

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  • DOI: https://doi.org/10.1007/s10867-018-9509-4

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