Journal of Biological Physics

, Volume 40, Issue 3, pp 259–266 | Cite as

Comment on “Modulating DNA configuration by interfacial traction: an elastic rod model to characterize DNA folding and unfolding”

  • Yongzhao Wang
  • Qichang Zhang
  • Wei Wang
Original Paper


In this comment, we point out that the tractions induced by interfacial energy, which are referred to as the tractions on the central axis curve of the DNA elastic rod presented by Huang (J. Biol. Phys. 37(1), 79–90, 2011), are incorrect. The correct tractions are provided in this literature. Further, with the use of the correct tractions, we present new numerical results, which for the values given by Zaixing Huang do not give rise to the physical behavior observed for DNA by the author.


DNA configuration Interfacial traction DNA folding and unfolding Comment 



The authors are grateful to the reviewer for comments and suggestions. The support of the National Nature Science Foundation of China through grant no. 11072168 and the Specialized Research Fund for Doctoral Program of Higher Education of China through grant no. 20100032120006 are gratefully acknowledged.


  1. 1.
    Benham, C.J., Mielke, S.P.: DNA mechanics. Annu. Rev. Biomed. Eng. 7, 21–53 (2005)CrossRefGoogle Scholar
  2. 2.
    Cherstvy, A.G.: Torque-induced deformations of charged elastic DNA rods: thin helices, loops, and precursors of DNA supercoiling. J. Biol. Phys. 37(2), 227–238 (2011)CrossRefGoogle Scholar
  3. 3.
    Cortini, R., Lee, D., Kornyshev, A.: Chiral electrostatics breaks the mirror symmetry of DNA supercoiling. J. Phys. Condens. Matter 24(16), 162,203 (2012)CrossRefGoogle Scholar
  4. 4.
    Huang, Z.: Modulating DNA configuration by interfacial traction: an elastic rod model to characterize DNA folding and unfolding. J. Biol. Phys. 37(1), 79–90 (2011)CrossRefGoogle Scholar
  5. 5.
    Hud, N.V., Downing, K.H., Balhorn, R.: A constant radius of curvature model for the organization of DNA in toroidal condensates. Proc. Nat. Acad. Sci. U.S.A. 92(8), 3581–3585 (1995)ADSCrossRefGoogle Scholar
  6. 6.
    Ma, L., Yethiraj, A., Chen, X., Cui, Q.: A computational framework for mechanical re-sponse of macromolecules:application to the salt concentration dependence of DNA bend-ability. Biophys. J. 96(8), 3543–3554 (2009)ADSCrossRefGoogle Scholar
  7. 7.
    Marichev, V.: Current state and problems in the surface tension of solids. Colloids Surf. A: Physicochem. Eng. Asp. 345(1), 1–12 (2009)CrossRefGoogle Scholar
  8. 8.
    Shi, Y., Borovik, A.E., Hearst, J.E.: Elastic rod model incorporating shear and extension, generalized nonlinear Schrödinger equations, and novel closed-form solutions for super-coiled DNA. J. Chem. Phys. 103(8), 3166–3183 (1995)ADSCrossRefGoogle Scholar
  9. 9.
    Shi, Y., Hearst, J.E.: The Kirchhoff elastic rod, the nonlinear Schrödinger equation, and DNA supercoiling. J. Chem. Phys. 101, 5186 (1994)ADSCrossRefGoogle Scholar
  10. 10.
    Starostin, E.L.: Three-dimensional shapes of looped DNA. Meccanica 31(3), 235–271 (1996)CrossRefMATHGoogle Scholar
  11. 11.
    Wang, W., Zhang, Q.C., Xie, Q.Z.: Analytical reduction of the non-circular Kirchhoff elastic rod model with the periodically varying bending rigidities. Physica Scripta 87(4), 045402 (2013)ADSCrossRefMathSciNetGoogle Scholar
  12. 12.
    Liu, Y.Z.: Nonlinear mechanics of thin elastic rod: theoretical basis of mechanical model of DNA (in Chinese). Tsinghua Press, Beijing (2006)Google Scholar
  13. 13.
    Yun, X., Yan-Zhu, L., Li-Qun, C.: The Schrödinger equation for a Kirchhoff elastic rod with noncircular cross-section. Chin. Phys. 13(6), 794 (2004)ADSCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.School of Mechanical EngineeringTianjin UniversityTianjinPeople’s Republic of China

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