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Dynamical patterns of calcium signaling in a functional model of neuron–astrocyte networks

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Abstract

We propose a functional mathematical model for neuron-astrocyte networks. The model incorporates elements of the tripartite synapse and the spatial branching structure of coupled astrocytes. We consider glutamate-induced calcium signaling as a specific mode of excitability and transmission in astrocytic–neuronal networks. We reproduce local and global dynamical patterns observed experimentally.

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Acknowledgements

This work was partly supported by the European Commission (NoE BioSim, Contract No. 4SHB-CT-2004-005137). N.B and A.B. acknowledge support from the Lundbeck Foundation and O.S. acknowledges the Skou grant from Forskningsraadet for Natur og Univers. D.P. and R.K. acknowledge support from the RFBR grant 090201049.

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Authors and Affiliations

  1. Physics Department, Saratov State University, Astrakhanskaya Street 83, Saratov, 410012, Russia

    D. E. Postnov & R. N. Koreshkov

  2. Biophysics Department, Biological Faculty, Moscow State University, Leninskie gory 1, Building 12, 119991, Moscow, Russia

    N. A. Brazhe & A. R. Brazhe

  3. Department of Physics, Technical University of Denmark, Building 309, 2800, Kongens Lyngby, Denmark

    O. V. Sosnovtseva

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  1. D. E. Postnov
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  2. R. N. Koreshkov
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  3. N. A. Brazhe
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  4. A. R. Brazhe
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  5. O. V. Sosnovtseva
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Correspondence to D. E. Postnov.

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Postnov, D.E., Koreshkov, R.N., Brazhe, N.A. et al. Dynamical patterns of calcium signaling in a functional model of neuron–astrocyte networks. J Biol Phys 35, 425–445 (2009). https://doi.org/10.1007/s10867-009-9156-x

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  • DOI: https://doi.org/10.1007/s10867-009-9156-x

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