A Computer-Glimpse of the Origin of Life
Evolution is assumed to begin in a very particular compartmentalized location with periodic conditions. A highly diversified world is the driving force for the continuous increase in complexity by colonizing increasingly less favourable regions. Modeling the “origin-of-life” a Darwinian cyclic process is simulated (multiplication with sporadic errors followed by a construction and selection).
Starting from a RNA-world (R-strands of R1 and R2 monomers building Hairpin-Assembler devices) and introducing another kind of monomers (A1 and A2 which interlink to the Hairpin-Assembler devices such that they become bound and form an A-oligomer) it is shown that a simple translation apparatus evolves producing enzymes (specific sequences of A1 and A2 monomers given by the sequences of R1 and R2 monomers on the assembler-strands). Later on D-strands are introduced, which are not capable of participating in the synthesis of A-oligomers. These D-strands become carriers of the genetic information and induce the formation of increasingly complex entities of functionally interplaying components.
Key wordsorigin of life evolution genetic apparatus genetic code emergence and storage of information self organisation fundamental conditions assembler hairpin RNA world assembler-hairpin-enzyme device RNA-protein world DNA-RNA-protein world computer simulation
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- Kuhn, H. and Waser, J.: Self-Organization of Matter and Early Evolution of Life, in W. Hoppe, W. Lohmann, H. Markl and H. Ziegler (eds.) Biophysics, Springer-Verlag, Berlin, 1983, pp. 830–874.Google Scholar
- Kuhn, H. and Waser, J.: A model of the origin of life and perspectives in supramolecular engineering in J.-P. Behr (ed.) Lock-and-Key Principle, Wiley, Chichester, 1994, pp. 247–306.Google Scholar
- Kuhn, C.: Computer-Modelling Origin of a Simple Genetic Apparatus, Proceedings of the National Academy of Sciences USA, 98 (2001), 8620–8626.Google Scholar
- Kuhn, H. and Kuhn, C.: Diversified World: Drive of Life's Origin?! Angew. Chemical International Edition 42 (2003), 262–266.Google Scholar