Visual analogue scale (VAS) measurement of antiretroviral adherence in people living with HIV (PLWH): a meta-analysis
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Effective treatment of HIV hinges upon maintaining adequate antiretroviral therapy adherence. Accurate, cost-effective measurement of medication adherence is needed to best respond to the HIV pandemic. The visual analogue scale (VAS) appears to be a simple and easy to use measure of adherence but the current literature on its use is mixed. This meta-analysis (1) describes VAS concordance with other measures of medication adherence and viral load; and (2) examines how research methods moderate the reported strength of the VAS–viral load relationship. Literature searches were conducted electronically and by hand with a total of 20 studies included in the present study. The VAS showed large strength associations with most other measures of adherence and a smaller association with viral load. More rigorous methodological quality significantly improved the VAS–viral load effect size. We conclude with optimization recommendations for VAS use in clinical practice and research design.
KeywordsHIV Medication adherence Visual analogue scale Viral load Adherence measurement Meta-analysis Methodological quality mHealth
This research was supported by U.S. Public Health Service Institutional National Research Service Award T32-MH074387 (PI: Seth C. Kalichman; trainees: David J. Finitsis and Jennifer A. Pellowski). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Compliance with ethical standards
Conflict of interest
David J. Finitsis, Jennifer A. Pellowski, Tania B. Huedo-Medina, Matthew C. Fox and Seth C. Kalichman declare that they have no conflict of interest.
Human and animal rights and Informed consent
All procedures followed were in accordance with ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all patients for being included in the study.
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