Journal of Behavioral Medicine

, Volume 35, Issue 2, pp 115–123 | Cite as

Does adherence-related support from physicians and partners predict medication adherence for vasculitis patients?

  • Jessica K. Pepper
  • Delesha M. Carpenter
  • Robert F. DeVellis


Few studies have explored mediators between medication-related support and medication adherence for individuals with rare, systemic autoimmune conditions. Using the Information-Motivation-Behavioral Skills model, we tested whether depressive symptomatology and medication adherence self-efficacy mediated the relationship between adherence support and changes in medication adherence among vasculitis patients, and whether support from physicians and partners differentially affected medication adherence. Vasculitis patients (n = 172) completed baseline and follow-up questionnaires about their medication adherence and perceived adherence support. Bootstrapped mediation analyses tested the effects of physician and partner support on changes in medication adherence. Adherence self-efficacy mediated the relationship between physician support and changes in medication adherence (B = 0.05, SE = 0.03, 95% CI 0.01, 0.13). Neither self-efficacy nor depressive symptomatology mediated the effects of partner support. Although physicians spend little time with patients, they can increase patients’ confidence about taking medications correctly and potentially improve health outcomes by bolstering medication adherence.


Medication adherence Social support Vasculitis Autoimmune conditions Depression Self-efficacy 


Conflict of interest

The authors have no conflict of interest to disclose.

Supplementary material

10865_2012_9405_MOESM1_ESM.doc (111 kb)
Supplementary material 1 (DOC 111 kb)
10865_2012_9405_MOESM2_ESM.doc (106 kb)
Supplementary material 2 (DOC 106 kb)


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Jessica K. Pepper
    • 1
  • Delesha M. Carpenter
    • 2
  • Robert F. DeVellis
    • 3
  1. 1.Department of Health Behavior and Health EducationUNC Gillings School of Global Public HealthChapel HillUSA
  2. 2.Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of PharmacyUniversity of North CarolinaChapel HillUSA
  3. 3.UNC Thurston Arthritis Research CenterUniversity of North CarolinaChapel HillUSA

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