Does adherence-related support from physicians and partners predict medication adherence for vasculitis patients?
- 272 Downloads
Few studies have explored mediators between medication-related support and medication adherence for individuals with rare, systemic autoimmune conditions. Using the Information-Motivation-Behavioral Skills model, we tested whether depressive symptomatology and medication adherence self-efficacy mediated the relationship between adherence support and changes in medication adherence among vasculitis patients, and whether support from physicians and partners differentially affected medication adherence. Vasculitis patients (n = 172) completed baseline and follow-up questionnaires about their medication adherence and perceived adherence support. Bootstrapped mediation analyses tested the effects of physician and partner support on changes in medication adherence. Adherence self-efficacy mediated the relationship between physician support and changes in medication adherence (B = 0.05, SE = 0.03, 95% CI 0.01, 0.13). Neither self-efficacy nor depressive symptomatology mediated the effects of partner support. Although physicians spend little time with patients, they can increase patients’ confidence about taking medications correctly and potentially improve health outcomes by bolstering medication adherence.
KeywordsMedication adherence Social support Vasculitis Autoimmune conditions Depression Self-efficacy
Conflict of interest
The authors have no conflict of interest to disclose.
- Fisher, J. D., & Fisher, W. A. (1992). The Information-Motivation Behavioral Skills model. In R. DiClemente, R. Crosby, & M. Kegler (Eds.), Emerging theories in health promotion practice and research (pp. 40–70). San Francisco, CA: Jossey Bass Publishers.Google Scholar
- Fisher, W. A., Fisher, J. D., & Harman, J. (2009). The Information-Motivation-Behavioral Skills model: A general social psychological approach to understanding and promoting health behavior. In J. Suls & K. A. Wallston (Eds.), Social psychological foundations of health and illness. Malden, MA: Blackwell Publishing Ltd.Google Scholar
- Hajj-Ali, R. A., Wilke, W. S., Calabrese, D. O., Hoffman, G. S., Liu, X., Bena, J., et al. (2011). Pilot study to assess the frequency of fibromyalgia, depression, and sleep disorders in patients with granulomatosis with polyangiitis (Wegener’s). Arthritis Care and Research, 6, 827–833.Google Scholar
- Haynes, R. B., Yao, X., Degani, A., Kripalani, S., Garg, A., & McDonald, H. P. (2006). Interventions for enhancing medication adherence. Cochrane Database Systematic Review, 4, 513–522.Google Scholar
- Hesse, B. W., Nelson, D. E., Kreps, G. L., Croyle, R. T., Arora, N. K., Rimer, B. K., et al. (2005). Trust and sources of health information: The impact of the internet and its implications for health care providers: Findings from the first Health Information National Trends Survey. Archives of Internal Medicine, 165, 2618–2624.PubMedCrossRefGoogle Scholar
- Holt-Lunstad, J., Birmingham, W., & Jones, B. Q. (2008). Is there something unique about marriage? The relative impact of marital status, relationship quality, and network social support on ambulatory blood pressure and mental health. Annals of Behavioral Medicine, 35, 239–244.PubMedCrossRefGoogle Scholar
- Kalichman, S. C., Rompa, D., DiFonzo, K., Simpson, D., Austin, J., Luke, W., et al. (2001). HIV treatment adherence in women living with HIV/AIDS: Research based on the Information-Motivation-Behavioral Skills model of health behavior. Journal of the Association of Nurses in AIDS Care, 12, 58–67.PubMedCrossRefGoogle Scholar
- Langford, C. A., Klippel, J. H., Balow, J. E., James, S. P., & Sneller, M. C. (1998). Use of cytotoxic agents and cyclosporine in the treatment of autoimmune disease: Part 2: Inflammatory bowel disease, systemic vasculitis, and therapeutic toxicity. Annals of Internal Medicine, 129, 49–58.PubMedGoogle Scholar
- Parienti, J. J., Massari, V., Descamps, D., Vabret, A., Bouvet, E., & Larouzé, B. (2004). Predictors of virologic failure and resistance in HIV-infected patients treated with nevirapine- or efavirenz-based antiretroviral therapy. Clinical Infectious Diseases, 38, 1311–1316.PubMedCrossRefGoogle Scholar
- Preacher, K. J., & Hayes, A. F. (2004). SPSS and SAS procedures for estimating indirect effects in simple mediation models. Behavior Research Methods, 36, 717–731.Google Scholar
- Remien, R. H., Hirky, A. E., Johnson, M. O., Weinhardt, L. S., Whittier, D., & Le, G. M. (2003). Adherence to medication treatment: A qualitative study of facilitators and barriers among a diverse sample of HIV+ men and women in four U.S. cities. AIDS and Behavior, 7, 61–72.PubMedCrossRefGoogle Scholar
- Rogers, P. G., & Bullman, W. R. (1995). Prescription medication compliance: A review of the baseline of knowledge. A report of the National Council on Patient Information and Patient Education. Pharmacoepidemiology and Drug Safety, 2, 3–36.Google Scholar
- Sackett, D. L., & Haynes, R. B. (Eds.). (1976). Compliance with therapeutic regimens. Baltimore, MD: Johns Hopkins University Press.Google Scholar
- Sobel, M. E. (1982). Asymptotic confidence intervals for indirect effects in structural equation models. In S. Leinhardt (Ed.), Sociological methodology (pp. 290–312). Washington, DC: American Sociological Association.Google Scholar
- Uchino, B. N. (2004). Social support and physical health: Understanding the health consequences of relationships. New Haven, CT: Yale University Press.Google Scholar