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Depression predicts failure to complete phase-II cardiac rehabilitation

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Abstract

Reduced adherence to medical treatment regimens may help to explain the higher risk of mortality among depressed cardiac patients. Participation in cardiac rehabilitation is a highly recommended part of the medical treatment regimen for cardiac patients. This study examined if elevated depressive symptomology, as measured by the Beck Depression Inventory (BDI), predicted failure to complete a 12-week phase II cardiac rehabilitation program for 600 patients. Logistic regression analysis showed that patients with elevated levels of depressive symptomology (BDI scores ≥ 10) were 2.2 times less likely to complete cardiac rehabilitation compared to patients without depression (BDI < 10), after controlling for age, gender, body mass index, and employment. Somatic symptoms predicted non-completion due to medical reasons, whereas younger age predicted failure to complete cardiac rehabilitation due to non-medical reasons. Given the difficulty of reducing mortality by treating depression directly, interventions targeting behavior change to improve medical treatment adherence might be an effective complementary strategy.

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References

  • American Association of Cardiovascular and Pulmonary Rehabilitation. (2004). Guidelines for cardiac rehabilitation and secondary prevention programs (4th ed.). Champaign, IL: Human Kinetics.

    Google Scholar 

  • Bane, C., Hughes, C. M., & McElnay, J. C. (2006). The impact of depressive symptoms and psychosocial factors on medication adherence in cardiovascular disease. Patient Education and Counseling, 60, 187–193. doi:10.1016/j.pec.2005.01.003.

    Article  PubMed  Google Scholar 

  • Beck, A. T., Ward, C. H., Mendelson, M., Mock, J., & Erbaugh, J. (1961). An inventory for measuring depression. Archives of General Psychiatry, 4, 561–571.

    PubMed  Google Scholar 

  • Berkman, L. F., Blumenthal, J., Burg, M., Carney, R. M., Catellier, D., Cowan, M. J., et al. (2003). Effects of treating depression and low perceived social support on clinical events after myocardial infarction: The Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) Randomized Trial. The Journal of the American Medical Association, 289, 3106–3116.

    Article  Google Scholar 

  • Blumenthal, J. A., Williams, R. S., Wallace, A. G., Williams, R. B. J., & Needles, T. L. (1982). Physiological and psychological variables predict compliance to prescribed exercise therapy in patients recovering from myocardial infarction. Psychosomatic Medicine, 44, 519–527.

    PubMed  Google Scholar 

  • Brodie, D. A., & Inoue, A. (2005). Motivational interviewing to promote physical activity for people with chronic heart failure. Journal of Advanced Nursing, 50, 518–527. doi:10.1111/j.1365-2648.2005.03422.x.

    Article  PubMed  Google Scholar 

  • Bruce, E. C., & Musselman, D. (2005). Depression, alterations in platelet function, and ischemic heart disease. Psychosomatic Medicine, 67, S34–S36. doi:10.1097/01.psy.0000164227.63647.d9.

    Article  PubMed  Google Scholar 

  • Carney, R. M., Blumenthal, J. A., Stein, P. K., Watkins, L., Catellier, D., Berkman, L. F., et al. (2001). Depression, heart rate variability, and acute myocardial infarction. Circulation, 104, 2024–2028. doi:10.1161/hc4201.097834.

    Article  PubMed  Google Scholar 

  • Carney, R. M., Freedland, K. E., Eisen, S. A., Rich, M. W., & Jaffe, A. S. (1995a). Major depression and medication adherence in elderly patients with coronary artery disease. Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association, 14, 88–90.

    Google Scholar 

  • Carney, R. M., Freedland, K. E., Miller, G. E., & Jaffe, A. S. (2002). Depression as a risk factor for cardiac mortality and morbidity: A review of potential mechanisms. Journal of Psychosomatic Research, 53, 897–902. doi:10.1016/S0022-3999(02)00311-2.

    Article  PubMed  Google Scholar 

  • Carney, R. M., Rich, M. W., teVelde, A., Saini, J., Clark, K., & Freedland, K. E. (1988). The relationship between heart rate, heart rate variability and depression in patients with coronary artery disease. Journal of Psychosomatic Research, 32, 159–164. doi:10.1016/0022-3999(88)90050-5.

    Article  PubMed  Google Scholar 

  • Carney, R. M., Saunders, R. D., Freedland, K. E., Stein, P., Rich, M. W., & Jaffe, A. S. (1995b). Association of depression with reduced heart rate variability in coronary artery disease. The American Journal of Cardiology, 76, 562–564. doi:10.1016/S0002-9149(99)80155-6.

    Article  PubMed  Google Scholar 

  • Caulin-Glaser, T., Maciejewski, P. K., Snow, R., Lalonde, M., & Mazure, C. (2007). Depressive symptoms and sex affect completion rates and clinical outcomes in cardiac rehabilitation. Preventive Cardiology, 10, 15–21. doi:10.1111/j.1520-037.2007.05666.x.

    Article  PubMed  Google Scholar 

  • Connerney, I., Shapiro, P. A., McLaughlin, J. S., Bagiella, E., & Sloan, R. P. (2001). Relation between depression after coronary artery bypass surgery and 12-month outcome: A prospective study. Lancet, 358, 1766–1771. doi:10.1016/S0140-6736(01)06803-9.

    Article  PubMed  Google Scholar 

  • Daly, J., Sindone, A. P., Thompson, D. R., Hancock, K., Chang, E., & Davidson, P. (2002). Barriers to participation in and adherence to cardiac rehabilitation programs: A critical literature review. Progress in Cardiovascular Nursing, 17, 8–17. doi:10.1111/j.0889-7204.2002.00614.x.

    Article  PubMed  Google Scholar 

  • Farley, R. L., Wade, T. D., & Birchmore, L. (2003). Factors influencing attendance at cardiac rehabilitation among coronary heart disease patients. European Journal of Cardiovascular Nursing: Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology, 2, 205–212.

    Google Scholar 

  • Frasure-Smith, N., Lesperance, F., Juneau, M., Talajic, M., & Bourassa, M. G. (1999). Gender, depression, and one-year prognosis after myocardial infarction. Psychosomatic Medicine, 61, 26–37.

    PubMed  Google Scholar 

  • Frasure-Smith, N., Lesperance, F., & Talajic, M. (1993). Depression following myocardial infarction. Impact on 6-month survival. The Journal of the American Medical Association, 270, 1819–1825.

    Article  Google Scholar 

  • Frasure-Smith, N., Lesperance, F., & Talajic, M. (1995). Depression and 18-month prognosis after myocardial infarction. Circulation, 91, 999–1005.

    PubMed  Google Scholar 

  • Freedland, K. E., Carney, R. M., & Skala, J. A. (2005). Depression and smoking in coronary heart disease. Psychosomatic Medicine, 67, S42–S46. doi:10.1097/01.psy.0000162255.55629.9c.

    Article  PubMed  Google Scholar 

  • Gehi, A., Haas, D., Pipkin, S., & Whooley, M. A. (2005). Depression and medication adherence in outpatients with coronary heart disease: Findings from the Heart and Soul Study. Archives of Internal Medicine, 165, 2508–2513. doi:10.1001/archinte.165.21.2508.

    Article  PubMed  Google Scholar 

  • Glassman, A. H., Helzer, J. E., Covey, L. S., Cottler, L. B., Stetner, F., Tipp, J. E., et al. (1990). Smoking, smoking cessation, and major depression. The Journal of the American Medical Association, 264, 1546–1549.

    Article  Google Scholar 

  • Glazer, K. M., Emery, C. F., Frid, D. J., & Banyasz, R. E. (2002). Psychological predictors of adherence and outcomes among patients in cardiac rehabilitation. Journal of Cardiopulmonary Rehabilitation, 22, 40–46. doi:10.1097/00008483-200201000-00006.

    Article  PubMed  Google Scholar 

  • Grace, S. L., Abbey, S. E., Irvine, J., Shnek, Z. M., & Stewart, D. E. (2004). Prospective examination of anxiety persistence and its relationship to cardiac symptoms and recurrent cardiac events. Psychotherapy and Psychosomatics, 73, 344–352. doi:10.1159/000080387.

    Article  PubMed  Google Scholar 

  • Hughes, J. W., Bartley, A. G., Casey, E., Luyster, F., Rosneck, J., Waechter, D., et al. (2006a). Depression symptoms are not a major impediment to enrollment in phase-II cardiac rehabilitation. Journal of Cardiopulmonary Rehabilitation, 26, 255. Ref Type. doi:10.1097/00008483-200607000-00030.

    Article  Google Scholar 

  • Hughes, J. W., Bartley, A. G., Casey, E., Luyster, F., Rosneck, J., Waechter, D., et al. (2006b). Depression symptoms are not a major impediment to enrollment in phase-II cardiac rehabilitation. Journal of Cardiopulmonary Rehabilitation, 26, 255. Abstract. doi:10.1097/00008483-200607000-00030.

    Article  Google Scholar 

  • Hughes, J., Casey, E., Luyster, F., Doe, V., Waechter, D., Rosneck, J., et al. (2006c). Depression symptoms predict heart rate recovery after treadmill stress testing. American Heart Journal, 151, 1122–1126. doi:10.1016/j.ahj.2006.02.004.

    Article  PubMed  Google Scholar 

  • Jeng, C., & Braun, L. T. (1997). The influence of self-efficacy on exercise intensity, compliance rate and cardiac rehabilitation outcomes among coronary artery disease patients. Progress in Cardiovascular Nursing, 12, 13–24.

    PubMed  Google Scholar 

  • Josephson, E., Casey, E., Waechter, D., Rosneck, J., & Hughes, J. W. (2006). Gender and depression symptoms in cardiac rehabilitation: Women initially exhibit higher depression scores but experience more improvement. Journal of Cardiopulmonary Rehabilitation, 26, 160–163. doi:10.1097/00008483-200605000-00008.

    Article  PubMed  Google Scholar 

  • Kop, W. J., & Gottdiener, J. S. (2005). The role of immune system parameters in the relationship between depression and coronary artery disease. Psychosomatic Medicine, 67, S37–S41. doi:10.1097/01.psy.0000162256.18710.4a.

    Article  PubMed  Google Scholar 

  • Kronish, I. M., Rieckmann, N., Halm, E. A., Shimbo, D., Vorchheimer, D., Haas, D. C., et al. (2006). Persistent depression affects adherence to secondary prevention behaviors after acute coronary syndromes. Journal of General Internal Medicine: Official Journal of the Society for Research and Education in Primary Care Internal Medicine, 21, 1178–1183.

    Google Scholar 

  • Lane, D., Carroll, D., Ring, C., Beevers, D. G., & Lip, G. Y. (2001). Predictors of attendance at cardiac rehabilitation after myocardial infarction. Journal of Psychosomatic Research, 51, 497–501. doi:10.1016/S0022-3999(01)00225-2.

    Article  PubMed  Google Scholar 

  • Lavie, C. J., & Milani, R. V. (1996). Effects of cardiac rehabilitation and exercise training programs in patients ≥75 years of age. The American Journal of Cardiology, 78, 675–677. doi:10.1016/S0002-9149(96)00393-1.

    Article  PubMed  Google Scholar 

  • Lavie, C. J., & Milani, R. V. (2006a). Adverse psychological and coronary risk profiles in young patients with coronary artery disease and benefits of formal cardiac rehabilitation. Archives of Internal Medicine, 166, 1878–1883. doi:10.1001/archinte.166.17.1878.

    Article  PubMed  Google Scholar 

  • Lavie, C. J., & Milani, R. V. (2006b). Cardiac rehabilitation, exercise training, and psychosocial risk factors. Journal of the American College of Cardiology, 47, 212. doi:10.1016/j.jacc.2005.10.002.

    Article  PubMed  Google Scholar 

  • Leon, A. S., Franklin, B. A., Costa, F., Balady, G. J., Berra, K. A., Stewart, K. J., et al. (2005). Cardiac rehabilitation and secondary prevention of coronary heart disease: An American Heart Association scientific statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity), in collaboration with the American association of Cardiovascular and Pulmonary Rehabilitation. Circulation, 111, 369–376. doi:10.1161/01.CIR.0000151788.08740.5C.

    Article  PubMed  Google Scholar 

  • Lesperance, F., Frasure-Smith, N., Juneau, M., & Theroux, P. (2000). Depression and 1-year prognosis in unstable angina. Archives of Internal Medicine, 160, 1354–1360. doi:10.1001/archinte.160.9.1354.

    Article  PubMed  Google Scholar 

  • Lesperance, F., Frasure-Smith, N., Talajic, M., & Bourassa, M. G. (2002). Five-year risk of cardiac mortality in relation to initial severity and one-year changes in depression symptoms after myocardial infarction. Circulation, 105, 1049–1053. doi:10.1161/hc0902.104707.

    Article  PubMed  Google Scholar 

  • Martens, E. J., Denollet, J., Pedersen, S. S., Scherders, M., Griez, E., Widdershoven, J., et al. (2006). Relative lack of depressive cognitions in post-myocardial infarction depression. Journal of Affective Disorders, 94, 231–237. doi:10.1016/j.jad.2006.04.023.

    Article  PubMed  Google Scholar 

  • Morgan, A., Masoudi, F., Havranek, E., Jones, P., Peterson, P., Krumholz, H., et al. (2006). Difficulty taking medications, depression, and health status in heart failure patients. Journal of Cardiac Failure, 12, 54–60. doi:10.1016/j.cardfail.2005.08.004.

    Article  PubMed  Google Scholar 

  • Oldridge, N. B., Donner, A. P., Buck, C. W., Jones, N. L., Andrew, G. M., Parker, J. O., et al. (1983). Predictors of dropout from cardiac exercise rehabilitation. Ontario Exercise-Heart Collaborative Study. The American Journal of Cardiology, 51, 70–74. doi:10.1016/S0002-9149(83)80013-7.

    Article  PubMed  Google Scholar 

  • Oldridge, N. B., & Stoedefalke, K. G. (1984). Compliance and motivation in cardiac exercise programs. Clinics in Sports Medicine, 3, 443–454.

    PubMed  Google Scholar 

  • Parashar, S., Rumsfeld, J. S., Spertus, J. A., Reid, K. J., Wenger, N. K., Krumholz, H. M., et al. (2006). Time course of depression and outcome of myocardial infarction. Archives of Internal Medicine, 166, 2035–2043. doi:10.1001/archinte.166.18.2035.

    Article  PubMed  Google Scholar 

  • Rieckmann, N., Gerin, W., Kronish, I. M., Burg, M. M., Chaplin, W. F., Kong, G., et al. (2006). Course of depressive symptoms and medication adherence after acute coronary syndromes: An electronic medication monitoring study. Journal of the American College of Cardiology, 48, 2218–2222. doi:10.1016/j.jacc.2006.07.063.

    Article  PubMed  Google Scholar 

  • Romanelli, J., Fauerbach, J. A., Bush, D. E., & Ziegelstein, R. C. (2002). The significance of depression in older patients after myocardial infarction. Journal of the American Geriatrics Society, 50, 817–822. doi:10.1046/j.1532-5415.2002.50205.x.

    Article  PubMed  Google Scholar 

  • Rozanski, A. (2005). Integrating psychologic approaches into the behavioral management of cardiac patients. Psychosomatic Medicine, 67(Suppl 1), S67–S73. doi:10.1097/01.psy.0000164252.07368.81.

    Article  PubMed  Google Scholar 

  • Ruo, B., Rumsfeld, J. S., Pipkin, S., & Whooley, M. A. (2004). Relation between depressive symptoms and treadmill exercise capacity in the Heart and Soul Study. The American Journal of Cardiology, 94, 96–99. doi:10.1016/j.amjcard.2004.03.035.

    Article  PubMed  Google Scholar 

  • Sanderson, B. K., & Bittner, V. (2005). Women in cardiac rehabilitation: Outcomes and identifying risk for dropout. American Heart Journal, 150, 1052–1058. doi:10.1016/j.ahj.2004.12.027.

    Article  PubMed  Google Scholar 

  • Sanderson, B. K., Phillips, M. M., Gerald, L., DiLillo, V., & Bittner, V. (2003). Factors associated with the failure of patients to complete cardiac rehabilitation for medical and nonmedical reasons. Journal of Cardiopulmonary Rehabilitation, 23, 281–289. doi:10.1097/00008483-200307000-00005.

    Article  PubMed  Google Scholar 

  • Scales, R., & Miller, J. H. (2003). Motivational techniques for improving compliance with an exercise program: Skills for primary care clinicians. Current Sports Medicine Reports, 2, 166–172. doi:10.1007/s11932-003-0051-0.

    PubMed  Google Scholar 

  • Sullivan, M., LaCroix, A., Russo, J., Swords, E., Sornson, M., & Katon, W. (1999). Depression in coronary heart disease. What is the appropriate diagnostic threshold? Psychosomatics, 40, 286–292.

    PubMed  Google Scholar 

  • Taylor, R. S., Brown, A., Ebrahim, S., Jolliffe, J., Noorani, H., Rees, K., et al. (2004). Exercise-based rehabilitation for patients with coronary heart disease: Systematic review and meta-analysis of randomized controlled trials. The American Journal of Medicine, 116, 682–692. doi:10.1016/j.amjmed.2004.01.009.

    Article  PubMed  Google Scholar 

  • Thornton, L. A. (2001). Depression in post-acute myocardial infarction patients. Journal of the American Academy of Nurse Practitioners, 13, 364–367.

    PubMed  Google Scholar 

  • Todaro, J., Shen, B., Niaura, R., & Tilkemeier, P. (2005). Prevalence of depressive disorders in men and women enrolled in cardiac rehabilitation. Journal of Cardiopulmonary Rehabilitation, 25, 71–75. doi:10.1097/00008483-200503000-00003.

    Article  PubMed  Google Scholar 

  • Turner, S. C., Bethell, H. J. N., Evans, J. A., Goddard, J. R., & Mullee, M. A. (2002). Patient characteristics and outcomes of cardiac rehabilitation. Journal of Cardiopulmonary Rehabilitation, 22, 253–260. doi:10.1097/00008483-200207000-00007.

    Article  PubMed  Google Scholar 

  • van Melle, J. P., De Jonge, P., Spijkerman, T. A., Tijssen, J. G. P., Ormel, J., van Veldhuisen, D. J., et al. (2004). Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: A meta-analysis. Psychosomatic Medicine, 66, 814–822. doi:10.1097/01.psy.0000146294.82810.9c.

    Article  PubMed  Google Scholar 

  • Wang, P., Bohn, R., Knight, E., Glynn, R., Mogun, H., & Avorn, J. (2002). Noncompliance with antihypertensive medications: the impact of depressive symptoms and psychosocial factors. Journal of General Internal Medicine: Official Journal of the Society for Research and Education in Primary Care Internal Medicine, 17, 504–511.

    Google Scholar 

  • Worcester, M. U. C., Murphy, B. M., Mee, V. K., Roberts, S. B., & Goble, A. J. (2004). Cardiac rehabilitation programmes: Predictors of non-attendance and drop-out. European Journal of Cardiovascular Prevention and Rehabilitation: Official Journal of the European Society of Cardiology. Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 11, 328–335.

    Google Scholar 

  • Ziegelstein, R. C., Fauerbach, J. A., Stevens, S. S., Romanelli, J., Richter, D. P., & Bush, D. E. (2000). Patients with depression are less likely to follow recommendations to reduce cardiac risk during recovery from a myocardial infarction. Archives of Internal Medicine, 160, 1818–1823. doi:10.1001/archinte.160.12.1818.

    Article  PubMed  Google Scholar 

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Casey, E., Hughes, J.W., Waechter, D. et al. Depression predicts failure to complete phase-II cardiac rehabilitation. J Behav Med 31, 421–431 (2008). https://doi.org/10.1007/s10865-008-9168-1

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