Journal of Bioenergetics and Biomembranes

, Volume 42, Issue 6, pp 441–442 | Cite as

Introduction to the mini-review series on mitochondrial matters in epilepsy

  • George H. SackJr.


Dysfunction of neuronal metabolism is central to all forms of seizure activity. Clinical, genetic and metabolic studies have implicated mitochondria in the process. Alterations in electron transport, generation of reactive oxygen species, calcium metabolism and apoptosis all have been described in human and animal nervous tissue and reflect changes in mitochondrial physiology. Improved understanding of the molecular details underlying seizures has begun to provide rational approaches to the design of new treatment strategies.


Seizure Mitochondrion Reactive oxygen species Mutation Apoptosis Electron transport 


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Departments of Medicine and Biological ChemistryThe Johns Hopkins University School of MedicineBaltimoreUSA

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