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Journal of Bioenergetics and Biomembranes

, Volume 42, Issue 4, pp 301–309 | Cite as

Beyond the Chemiosmotic Theory: Analysis of Key Fundamental Aspects of Energy Coupling in Oxidative Phosphorylation in the Light of a Torsional Mechanism of Energy Transduction and ATP Synthesis—Invited Review Part 2

  • Sunil Nath
Article

Abstract

The core of this second article shows how logical errors and inconsistencies in previous theories of energy coupling in oxidative phosphorylation are overcome by use of a torsional mechanism and the unified theory of ATP synthesis/hydrolysis. The torsional mechanism is shown to satisfy the pioneering and verified features of previous mechanisms. A considerable amount of data is identified that is incompatible with older theories but is now explained in a logically consistent and unified way. Key deficiencies in older theories are pinpointed and their resolution elucidated. Finally, major differences between old and new approaches are tabulated. The new theory now provides the elusive details of energy coupling and transduction, and allows several novel and experimentally verifiable predictions to be made and a considerable number of applications in nanotechnology, energy conversion, systems biology, and in health and disease are foreseen.

Keywords

Bioenergetics F1FO-ATP synthase Oxidative Phosphorylation Photosynthesis and photophosphorylation Mitochondria Energy transduction Chemiosmotic theory Torsional mechanism Coupling Membrane and ion transport Electrogenic Electroneutral Valinomycin Uncoupler Unified theory of ATP synthesis and hydrolysis 

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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Biochemical Engineering and BiotechnologyIndian Institute of TechnologyNew DelhiIndia

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