Journal of Bioenergetics and Biomembranes

, Volume 42, Issue 3, pp 189–191 | Cite as

Mitochondrial matters in Huntington disease

  • George H. SackJr.


Huntington Disease (HD) is a relatively common inherited neuropathy with characteristic cognitive and behavioral features. HD usually has a late onset and often is not recognized until the third or fourth decades of life. Transmitted as an autosomal dominant trait, HD has become a prototype for understanding a group of neurogenetic disorders. As a class, HD and the others are manifestations of the expansion of a trinucleotide repeat within the gene coding or structural region. In HD expansion of the (CAG)n repeat in the first exon from an average of 18 (normal) to a median of 44 is the underlying molecular biologic change. In affected individuals, the mutant HD protein (Huntingtin, mHtt) thus contains an extended polyglutamine repeat. Clinical and neuropathic changes in the caudate and putamen nuclei occur relatively early with other brain regions being affected later. Mitochondrial structure, altered electron transport and increased brain lactate levels have implicated mitochondria in HD pathophysiology. There is also evidence that reduced transcription of the peroxisome proliferator-activated receptor-γ coactivator (PGC-1α) leads to altered downstream gene regulation. Further evidence for mitochondrial involvement is presented in the following reviews. Clarifying mitochondrial derangements has led to some possibilities for therapeutic intervention.


Huntington DNA amplification DNA repeat Movement disorder Mitochondrion Neuropathy Reactive oxygen species PGC-1α 


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Departments of Medicine and Biological ChemistryThe Johns Hopkins School of MedicineBaltimoreUSA

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