Oxygen metabolism and a potential role for cytochrome c oxidase in the Warburg effect
By manipulating the physical properties of oxygen, cells are able to harvest the large thermodynamic potential of oxidation to provide a substantial fraction of the energy necessary for cellular processes. The enzyme largely responsible for this oxygen manipulation is cytochrome c oxidase, which resides at the inner mitochondrial membrane. For unknown reasons, cancer cells do not maximally utilize this process, but instead rely more on an anaerobic-like metabolism demonstrating the so-called Warburg effect. As the enzyme at the crossroads of oxidative metabolism, cytochrome c oxidase might be expected to play a role in this so-called Warburg effect. Through protein assay methods and metabolic studies with radiolabeled glucose, alterations associated with cancer and cytochrome c oxidase subunit levels are explored. The implications of these findings for cancer research are discussed briefly.
KeywordsCancer Cytochrome c oxidase Metabolism Oxygen Warburg
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- Herrmann PC (1996) Synthetic models of cytochrome c oxidase and myoglobin. Dissertation, Stanford University Department of Chemistry, pp 1–28Google Scholar
- Holmes FL (1985) Lavoisier and the chemistry of life: an exploration of scientific creativity. University of Wisconsin Press, MadisonGoogle Scholar
- Lee N, Morin C, Mitchell G, Robinson BH (1998) Biochim Biophys Acta 1406:1–4Google Scholar
- Nakashima RA, Paggi MG, Pedersen PL (1984) Cancer Res 44:5702–5706Google Scholar
- Pedersen PL (1978) Prog Exp Tumor Res 22:190–274Google Scholar
- Warburg O (1929) Biochem Z 204:482–494Google Scholar
- Warburg O (1930) Metabolism of tumors. Arnold Constable, LondonGoogle Scholar
- Warburg O, Kubowitz F (1927) Biochem Z 189:242–249Google Scholar
- Warburg O, Negelein E (1928) Biochem Z 193:334–339Google Scholar
- Warburg O, Posenor K, Negelein E (1924) Biochem Z 152:309–345Google Scholar