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Dietary fatty acid composition differently influences retinoylation reaction in rat testes mitochondria

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Abstract

All-trans-retinoic acid (atRA) is incorporated covalently into proteins of rat testes mitochondria. In this study, the effect of three diets with different fatty acid composition on the retinoylation of proteins of rat testes mitochondria has been investigated. Different groups of rats were fed on a basal diet supplemented with 15% of either coconut oil (CO), olive oil (OO) or fish oil (FO). We found that, when compared with CO, the binding of retinoic acid was decreased in FO- and OO-fed rats. Mitochondrial phospholipids composition was differently influenced by dietary treatments; minor changes were observed in fatty acid composition of phospholipids. Few differences were observed in the Arrhenius plots among the three groups of rats. Kinetic analysis revealed a decrease in the V max value in FO- and OO- as compared with CO-fed rats. No difference among the three groups were observed in the K M value. The retinoylation reaction was inhibited by 13-cis-RA and 9-cis-RA.

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Authors and Affiliations

  1. Department of Pharmaco-Biology, Laboratory of Biochemistry, University of Calabria, Edificio Polifunzionale, 87036, Rende (CS), Italy

    Erika Cione, Valentina Senatore, Paola Tucci & Giuseppe Genchi

  2. Department of Biological and Environmental Sciences and Technologies,Laboratory of Biochemistry , University of Lecce, Via Provinciale Lecce-Monteroni, 73100, Lecce, Italy

    Anna M. Giudetti & Gabriele V. Gnoni

  3. Department of Pharmaco-Biology, Laboratory of Biochemistry, University of Bari, via Orabona 4, 70125, Bari, Italy

    Francesco Genchi

  4. Dipartimento Farmaco-Biologico, Università della Calabria, 87036, Rende (CS), Italy

    Giuseppe Genchi

Authors
  1. Erika Cione
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  2. Valentina Senatore
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  3. Paola Tucci
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  4. Anna M. Giudetti
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  5. Francesco Genchi
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  6. Gabriele V. Gnoni
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  7. Giuseppe Genchi
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Correspondence to Giuseppe Genchi.

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Cione, E., Senatore, V., Tucci, P. et al. Dietary fatty acid composition differently influences retinoylation reaction in rat testes mitochondria. J Bioenerg Biomembr 39, 203–209 (2007). https://doi.org/10.1007/s10863-007-9078-x

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  • DOI: https://doi.org/10.1007/s10863-007-9078-x

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