NMR structure note: the ferrous iron transport protein C (FeoC) from Klebsiella pneumoniae
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Iron is an essential nutrient involved in many important biological processes ranging from electron transfer, oxygen transport, gene regulation, photosynthesis, N2 fixation to DNA biosynthesis (Andrews et al. 2003). Thus, the ability to acquire sufficient quantities of iron from the environment is vital for the survival of living organisms. This is particularly true for pathogens that must compete with the host iron-withdrawal response for their iron supplies. However, iron is also toxic and excess iron can be detrimental for the living system (Touati 2000). It is, therefore, essential for almost all life forms to maintain proper iron homeostasis (Andrews et al. 2003).
Feo is a unique ferrous iron transporter commonly utilized by bacterial systems for acquiring ferrous iron from the environment (Cartron et al. 2006). It was first discovered in Escherichia coli K-12 (Hantke 1987). Subsequently the feo locus was cloned and sequenced (Kammler et al. 1993). The...
KeywordsDihedral Angle Restraint Ferrous Iron Transport Hydrogen Bond Restraint Iron Restricted Condition Dependent Transcriptional Regulator
This work was supported by a grant (NSC 100-2311-B-001-023) from The National Science Council of the Republic of China. The NMR experiments were carried out with NMR spectrometers of the High-Field Nuclear Magnetic Resonance Center (HFNMRC) supported by National Research Program for Genomic Medicine, The National Science Council of the Republic of China.
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