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Relaxation-optimised Hartmann–Hahn transfer using a specifically Tailored MOCCA-XY16 mixing sequence for carbonyl–carbonyl correlation spectroscopy in 13C direct detection NMR experiments

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Abstract

Isotropic mixing sequences are one of the key methods to achieve efficient coherence transfer. Among them, the MOCCA-XY16, which keeps the magnetization longitudinal for a significant amount of time, is characterised by favourable relaxation properties. We show here that its adapted version is particularly suited for carbonyl–carbonyl correlations in 13C direct detection NMR experiments.

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Acknowledgments

This work has been supported in part by the EC contracts EU-NMR n° 026145 (TA and JRA) and SPINE II n° 031220 and by Ente Cassa di Risparmio di Firenze. S. J. G. and B. L. thank the Fonds der Chemischen Industrie and the Deutsche Forschungsgemeinschaft for financial support (GL 203/6–1; Emmy Noether and Heisenberg fellowships LU 835/1–4 and LU 835/2–1). B. L. thanks the Center for Integrated Protein Science Munich (CIPSM) for financial support. Prof. Ivano Bertini is gratefully acknowledged for stimulating discussions.

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Authors and Affiliations

  1. Department of Chemistry and Magnetic Resonance Center (CERM), University of Florence, Via Luigi Sacconi 6, 50019, Sesto Fiorentino, Florence, Italy

    Isabella C. Felli & Roberta Pierattelli

  2. Department of Chemistry, Technische Universität München, Lichtenbergstr. 4, 85747, Garching, Germany

    Steffen J. Glaser & Burkhard Luy

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  1. Isabella C. Felli
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  2. Roberta Pierattelli
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  3. Steffen J. Glaser
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  4. Burkhard Luy
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Correspondence to Burkhard Luy.

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Felli, I.C., Pierattelli, R., Glaser, S.J. et al. Relaxation-optimised Hartmann–Hahn transfer using a specifically Tailored MOCCA-XY16 mixing sequence for carbonyl–carbonyl correlation spectroscopy in 13C direct detection NMR experiments. J Biomol NMR 43, 187–196 (2009). https://doi.org/10.1007/s10858-009-9302-6

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